Rhythmic forces shaping the zebrafish cardiac system - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39665884/
The structural development of the heart depends heavily on mechanical forces, and rhythmic contractions generate essential physical stimuli during morphogenesis. Cardiac cells play a critical role in coordinating this process...
Mechanical forces during heart development regulate cell identity and morphogenesis, with zebrafish studies revealing how dynamic stresses influence endocardial and myocardial behavior, including valve formation and trabeculation.
Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39034866/
Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left...
Systemic aging drives cardiac and vascular decline via inflammation, senescence, and metabolic dysfunction, increasing heart failure risk. Interventions include exercise, diet, senotherapeutics, and metabolic or anti-inflammatory therapies.
Use of Guideline-Recommended Heart Failure Drugs in High-, Middle-, and Low-Income Countries: A Systematic Review and Meta-Analysis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39281002/
Optimal use of guideline-directed medical therapy (GDMT) can prevent hospitalization and mortality among patients with heart failure (HF). We aimed to assess the prevalence of GDMT use for HF across...
GDMT use for HFrEF has increased globally, especially in high-income countries, but remains suboptimal in low- and middle-income regions, highlighting a need for multi-level interventions to improve access.
Get With the Guidelines-Heart Failure: Twenty Years in Review, Lessons Learned, and the Road Ahead - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/40351187/
The Get With the Guidelines-Heart Failure program was developed in 2005 with the goal of bringing evidence-based guidelines in heart failure management into widespread clinical practice. The program includes workshops,...
The Get With the Guidelines-Heart Failure program has enhanced heart failure care across 600+ U.S. hospitals, improving outcomes through evidence-based practices, data integration, and ongoing quality improvement efforts.
Obesity and heart failure with preserved ejection fraction: focus on new drugs and future direction in medical treatment - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/40360219/
Obesity is a major risk factor for heart failure with preserved ejection fraction (HFpEF) and contributes through multiple pathophysiological pathways, including systemic inflammation, neurohormonal activation, and mechanical inhibition. The treatment...
Obesity significantly impacts HFpEF through inflammation and mechanical stress; GLP-1 RAs and SGLT2 inhibitors show promise in improving symptoms, weight loss, and outcomes in obesity-related HFpEF.