Researchers engaged key stakeholders in human-centered design sessions to identify challenges in guideline-directed medical therapies optimization posthospitalization and inform the development of a digital toolkit aimed at optimizing HF therapy. Several themes emerged from the clinician, patient, and caregiver sessions on challenges to...

EMPA causes a switch in metabolism away from glucose oxidation toward increased ketone utilisation in the rat heart, thereby improving function and energetics both during ischaemia and recovery during reperfusion. This preference of ketone utilisation over glucose was observed under conditions of constant supply of substrate, suggesting that...

This real-world study of empagliflozin use in the inpatient setting found no significant differences in safety endpoints between empagliflozin and other oral antihyperglycemic agents. Larger-scale studies need to be performed before the use of empagliflozin can be routinely recommended in the inpatient setting.