11mo
Heart Failure Connect
11mo
Interplay of Chronic Kidney Disease and the Effects of Tirzepatide in Patients With Heart Failure, Preserved Ejection Fraction, and Obesity: The SUMMIT Trial - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/40162940/
The triad of obesity, HFpEF, and CKD identifies patients with considerable functional impairment and an unfavorable prognosis, who nevertheless respond favorably to tirzepatide. Long-term tirzepatide improves renal function (both by...
In obese HFpEF patients, tirzepatide improved heart failure outcomes and renal function regardless of CKD status, though eGFR assessments varied by biomarker due to body composition effects on creatinine and cystatin C.
11mo
The utility of urine sodium-guided diuresis during acute decompensated heart failure - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39128947/
Diuresis to achieve decongestion is a central aim of therapy in patients hospitalized for acute decompensated heart failure (ADHF). While multiple approaches have been tried to achieve adequate decongestion rapidly...
This review highlights urine sodium-guided diuresis as a promising approach for optimizing decongestion in ADHF, emphasizing current evidence, knowledge gaps, and emerging trials evaluating its clinical utility and outcomes.
11mo
Association between the haemoglobin glycation index (HGI) and clinical outcomes in patients with acute decompensated heart failure - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38513606/
A high HGI was directly associated with a reduction in all-cause and CV deaths but was not associated with MACE. These findings may be helpful in the management of patients...
Higher haemoglobin glycation index (HGI) in ADHF patients was linked to significantly lower all-cause and cardiovascular mortality, suggesting HGI may enhance risk stratification beyond HbA1c in clinical management.
1yr
Cardiovascular diseases lead EU deaths but are 80% preventable. A 2024 analysis highlights fine dust, nitrogen dioxide, and drug factors as key mortality drivers. Coordinated prevention addressing environment and behavior is urgently needed.
Learn more from the full study.