Pediatric coronary cameral fistula in a structurally normal heart: a case report and review of the literature - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39300528/
Timely identification and management of coronary cameral fistulae are crucial to prevent complications. Advances in imaging techniques and minimally invasive treatments, such as transcatheter closure, offer effective solutions. A multidisciplinary...
A 5-year-old boy with a coronary cameral fistula was successfully treated using Amplatzer™ devices, emphasizing the importance of multimodal imaging and timely intervention to prevent heart failure and ischemia.
Epicardial Adipose Tissue Thickness and Preserved Ejection Fraction Heart Failure - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38642285/
Body mass index correlates poorly with visceral, and epicardial adiposity. Visceral and epicardial adiposity enlarges as preserved ejection fraction heart failure progresses. Epicardial adiposity may hasten the progression of coronary...
Immunomodulating and Immunosuppressive Therapy for Virus-Negative Immune-Mediated Myocarditis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39062138/
Myocarditis is an inflammatory disease of the myocardium caused by infectious and noninfectious agents. Clinical manifestations range from mildly symptomatic forms to acute heart failure, cardiogenic shock, life-threatening arrhythmias and...
Myocarditis, an inflammatory heart condition, presents varying symptoms. Immunosuppressive therapy is debated, though effective in specific cases. Diagnosis via endomyocardial biopsy guides tailored treatment strategies.
Update: factors influencing heart rate variability-a narrative review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39165281/
In order to improve the quality of HRV studies and to ensure accurate interpretation, it is recommended that confounders be taken into account in future diagnostic measurements or measurements in...
This narrative review highlights factors influencing heart rate variability (HRV), categorizing them as non-influenceable physiological factors, diseases, lifestyle choices, and external elements, stressing the importance of considering these confounders in HRV interpretation.
Heart Failure: a Punch from the Gut
Source : https://pubmed.ncbi.nlm.nih.gov/38300390/
A growing field of research is focused on the effects of a "leaky gut" in the development of disease across organ systems. The leaky gut hypothesis centers on intestinal epithelial...
Targeting gut composition may significantly improve heart failure (HF) outcomes by addressing gut dysbiosis and epithelial barrier dysfunction, highlighting a crucial therapeutic avenue.
Left Ventricular Function, Congestion, and Effect of Empagliflozin on Heart Failure Risk After Myocardial Infarction
Source : https://pubmed.ncbi.nlm.nih.gov/38588929/
In patients with AMI, the severity of left ventricular dysfunction and the presence of congestion was associated with worse outcomes. Empagliflozin reduced first and total HF hospitalizations across the range...
Empagliflozin reduced HF hospitalizations post-AMI, regardless of LVEF or congestion, with consistent safety. Severity of LVEF dysfunction and congestion correlated with worse outcomes.
Where Are We With Treatment and Prevention of Heart Failure in Patients Post-Myocardial Infarction
Source : https://pubmed.ncbi.nlm.nih.gov/38878010/
As a result of the widespread use of reperfusion therapies and secondary prevention over the last 30 years, there has been a dramatic reduction in the risk of mortality and...
Despite advances in reperfusion and secondary prevention, chronic heart failure (HF) remains common post-myocardial infarction (MI). Neurohormonal inhibition and emerging therapies aim to mitigate HF risk and myocardial damage.
The current best drug treatment for hypertensive heart failure with preserved ejection fraction
Source : https://pubmed.ncbi.nlm.nih.gov/37865559/
More than 90 % of patients developing heart failure (HF) have hypertension. The most frequent concomitant conditions are type-2 diabetes mellitus, obesity, atrial fibrillation, and coronary disease. HF outcome research...
Heart failure (HF) treatment involves antihypertensives and other drugs, regardless of left ventricular ejection fraction (LVEF). Focus on symptom management, signs, severity, and comorbid conditions.
Heart Transplantation
Source : https://pubmed.ncbi.nlm.nih.gov/38256691/
Heart transplantation (HTx) remains the last therapeutic resort for patients with advanced heart failure. The present work is a clinically focused review discussing current issues in heart transplantation. Several factors...
Heart transplantation advances include xenotransplantation, hepatitis C donors, improved rejection monitoring, and novel immunosuppressants, enhancing outcomes for patients with advanced heart failure.
Exercise intolerance in heart failure with preserved ejection fraction: Causes, consequences and the journey towards a cure
Source : https://pubmed.ncbi.nlm.nih.gov/38063130/
Heart failure with preserved ejection fraction (HFpEF) accounts for over 50% of all heart failure cases nationwide and continues to rise in its prevalence. The complex, multi-organ involvement of the...
HFpEF's complex pathophysiology involves both cardiac and non-cardiac factors. Improving vascular health through interventions could enhance outcomes, underscoring the need for an integrative approach to treatment.
Diuretic Treatment in Patients with Heart Failure: Current Evidence and Future Directions-Part II: Combination Therapy
Source : https://pubmed.ncbi.nlm.nih.gov/38300391/
We will assess recent trials, including DOSE, TRANSFORM, ADVOR, CLOROTIC, OSPREY-AHF, and PUSH-AHF, and assess how these may influence current practice and future research. There are few data on which...
Fluid retention in heart failure (HF) is managed primarily with loop diuretics, needing updated research to optimize treatment strategies and improve guidelines.
Advances in device-based treatment of heart failure with preserved ejection fraction: evidence from clinical trials
Source : https://pubmed.ncbi.nlm.nih.gov/37986663/
Heart failure with preserved ejection fraction (HFpEF) is a group of clinical syndromes that exhibit a remarkably heterogeneous phenotype, characterized by symptoms and signs of heart failure, left ventricular diastolic...
HFpEF is a complex heart failure syndrome with limited drug therapies. Emerging device-based therapies show promise in improving symptoms and reducing readmissions.
Heart failure pharmacotherapy and cancer: pathways and pre-clinical/clinical evidence
Source : https://pubmed.ncbi.nlm.nih.gov/38441940/
Heart failure (HF) patients have a significantly higher risk of new-onset cancer and cancer-associated mortality, compared to subjects free of HF. While both the prevention and treatment of new-onset HF...
Guideline-directed medical therapy for heart failure may influence cancer incidence and outcomes. Future research should refine HF treatment strategies in the context of coexisting cancer.
Antiarrhythmic Treatment in Heart Failure
Source : https://pubmed.ncbi.nlm.nih.gov/38224446/
In atrial fibrillation, rhythm control and ventricular rate control are accepted therapeutic strategies. In recent years, clinical trials have demonstrated a prognostic benefit of early rhythm control strategies and AF...
Antiarrhythmic therapy in HF requires a systematic, multimodal approach, integrating pharmacological, device, and interventional therapy for optimal outcomes.
Heart failure in nursing homes: A scoping review of educational interventions for optimising care provision
Source : https://pubmed.ncbi.nlm.nih.gov/38746815/
There is a paucity of evidence around educational interventions to support residents living with heart failure in nursing homes. However, available evidence suggests that educational interventions in nursing homes may...
There is a paucity of evidence around educational interventions to support residents living with heart failure in nursing homes. However, available evidence suggests that educational interventions in nursing homes may improve care through improving staff self-efficacy and confidence in providing care, heart failure knowledge and...
Diastolic Heart Failure Mechanisms and Assessment Revisited
Source : https://pubmed.ncbi.nlm.nih.gov/38892754/
The syndrome of heart failure (HF) with preserved ejection fraction (HFpEF) makes up about half of the HF population. The HF mechanisms in these patients are varied and not fully...
Understand and address heart failure with preserved ejection fraction (HFpEF), highlighting its complex mechanisms and the urgency for early recognition and treatment to mitigate its progression and impact, particularly given its increasing prevalence in an aging population.
Full decongestion in acute heart failure therapy
Source : https://pubmed.ncbi.nlm.nih.gov/38880301/
Incomplete decongestion is the main cause of readmission in the early post-discharge period of a hospitalization for acute heart failure. Recent heart failure guidelines have highlighted initiation and rapid up-titration...
Achieving complete decongestion remains the primary therapeutic objective during hospitalization for heart failure, with early initiation and titration of quadruple therapy recommended to prevent readmissions for heart failure with reduced ejection fraction.
The Role of Inflammasomes in Heart Failure
Source : https://pubmed.ncbi.nlm.nih.gov/38791409/
Heart failure (HF) poses a significant world health challenge due to the increase in the aging population and advancements in cardiac care. In the pathophysiology of HF, the inflammasome has...
Understanding the role of inflammasomes in heart failure (HF) pathophysiology reveals their potential as biomarkers and therapeutic targets. Modulating inflammasome signaling could offer innovative strategies for managing HF.
Effect of Empagliflozin on Heart Failure Outcomes After Acute Myocardial Infarction: Insights From the EMPACT-MI Trial
Source : https://pubmed.ncbi.nlm.nih.gov/38581389/
URL: https://www.clinicaltrials.gov; Unique identifier: NCT04509674.
Empagliflozin reduced the risk of HF in patients with left ventricular dysfunction or congestion after acute myocardial infarction.
2024 update in heart failure
Source : https://pubmed.ncbi.nlm.nih.gov/38806171/
In the last years, major progress has occurred in heart failure (HF) management. The 2023 ESC focused update of the 2021 HF guidelines introduced new key recommendations based on the...
Recent updates in heart failure management highlight significant advances such as the use of SGLT2 inhibitors and finerenone for prevention in diabetic CKD, and expanded treatments across HF spectrums. Emerging therapies like vericiguat and semaglutide show promise, while ongoing research continues to refine treatment strategies.