Therapeutic Efficacy and Safety of Paracetamol versus Ibuprofen in Patent Ductus Arteriosus in Newborns: A Systematic Review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39661802/
Closure of the ductus arteriosus (DA) using cyclooxygenase (COX) inhibitors is considered the first-line treatment for hemodynamically significant patent ductus arteriosus (PDA). Physiologically, prostaglandins have a recognized role in PDA....
Acetaminophen and ibuprofen show equivalent efficacy and safety for closing patent ductus arteriosus in preterm newborns, with no significant differences in adverse effects, supporting either as viable first-line therapies.
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Serum Biomarkers in Patent Ductus Arteriosus in Preterm Infants: A Narrative Review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/40149646/
Background : Patent ductus arteriosus (PDA) in preterm infants presents a significant challenge in neonatal care, marked by ongoing debates about its definition, diagnosis, treatment options, and effects on patient...
Plasma biomarkers like natriuretic peptides and inflammatory markers show strong correlations with PDA in preterm infants, aiding diagnosis and risk assessment, though clinical judgment remains essential in treatment decisions.
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Keeping the Ductus Arteriosus Patent: Current Strategy and Perspectives - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39941172/
Patent ductus arteriosus (PDA) continues to be a significant finding among infants, as well as adults. What is widely considered to be a problem though, in a group of patients...
Patent ductus arteriosus, vital in certain congenital heart diseases, requires precise management to maintain circulation; this review explores anatomical, biochemical, pharmacological, and surgical strategies, emphasizing knowledge gaps in endothelial function.
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Complications of transvenous lead extraction-focus on tricuspid valve damage: a case report - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39811751/
While pre-procedural TTE and intra-procedural transesophageal echocardiography are commonly used to identify lead-induced tricuspid insufficiency, they often do not clarify the underlying mechanisms or predict potential complications during TLE. To...
An 84-year-old man developed acute tricuspid regurgitation from leaflet avulsion during transvenous lead extraction; successful valve replacement and reimplantation highlight the need for improved imaging to predict TLE complications.
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Epigenetics in Heart Failure - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39596076/
Heart failure is a clinical syndrome with rising global incidence and poor prognosis despite improvements in medical therapy. There is increasing research interest in epigenetic therapies for heart failure. Pathological...
Epigenetic modifications, including DNA and histone changes, drive cardiac remodeling in heart failure. Emerging therapies target these mechanisms, offering potential for novel biomarkers and personalized treatment approaches.
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