These findings provide insight into the shared pathobiology of heart failure and frailty in late life and suggest potential molecular pathways that can be targeted by interventions to mitigate the burden of both conditions.
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Sodium-glucose cotransporter 2 inhibitor dapagliflozin prevents ejection fraction reduction, reduces myocardial and renal NF-κB expression and systemic pro-inflammatory biomarkers in models of short-term doxorubicin cardiotoxicity
Source : https://pubmed.ncbi.nlm.nih.gov/38818214/
The overall picture of the study encourages the use of DAPA in the primary prevention of cardiomyopathies induced by anthracyclines in patients with cancer.
The overall picture of the study encourages the use of DAPA in the primary prevention of cardiomyopathies induced by anthracyclines in patients with cancer.
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Atrial fibrillation: pathophysiology, genetic and epigenetic mechanisms
Source : https://pubmed.ncbi.nlm.nih.gov/38722319/
In summary, this study underscores that, despite the influence of biologic therapy on certain markers, standard allergy tests remain viable while emphasizing the importance of considering specific IgE levels rather...
In summary, this study underscores that, despite the influence of biologic therapy on certain markers, standard allergy tests remain viable while emphasizing the importance of considering specific IgE levels rather than relying solely on CAP classes. The Skin Prick Test in particular proves to be a reliable tool for identifying sensitizations...
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Amyloid and collagen templates in aortic valve calcification
Source : https://pubmed.ncbi.nlm.nih.gov/38845326/
Calcific aortic valve disease (CAVD) is a widely prevalent heart disorder in need of pharmacological interventions. Calcified areas in aortic valves often contain amyloid fibrils that promote calcification in vitro....
Lipoprotein(a), a genetic risk factor for CAVD, augments calcification via several mechanisms, wherein hydrolysis of oxidized phospholipids (oxPLs) by Lp(a)-associated enzymes helps generate orthophosphate, and apolipoprotein(a) blocks plasmin-induced fibril degradation. Current studies of amyloid-calcium-collagen interactions in solution and...
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Patients living with HIV infection had a higher risk of all-cause mortality, major adverse CV events, recurrent acute coronary syndromes, and admission for HF after the index event, despite being approximately 11 years younger at the time of the event.
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