Source : https://pubmed.ncbi.nlm.nih.gov/39160066/
For patients with heart failure and reduced or mildly reduced left ventricular ejection fraction, iron deficiency is common and associated with more severe symptoms, worse quality of life and an...
Iron deficiency in heart failure worsens outcomes but improves with intravenous iron therapy. Current diagnostic criteria are flawed; targeting transferrin saturation <20% may enhance treatment response and patient care.
Source : https://pubmed.ncbi.nlm.nih.gov/38858610/
In this case, based on negative tests and the absence of viral signs and symptoms, Cancer therapy-related myocarditis is highly suspected as the cause of myocarditis. This case underscores the...
A 19-year-old with ES/PNET treated with VAC/IE developed chemotherapy-related myocarditis. Diagnosed via CMR, she responded significantly to IVIG, improving LVEF, highlighting its potential for treating reversible myocarditis.
Source : https://pubmed.ncbi.nlm.nih.gov/38265835/
ClinicalTrials.gov Identifier: NCT03619213.
Dapagliflozin reduces cardiovascular death, particularly sudden death, in HFimpEF patients, supporting its use with guideline-directed therapies to lower mortality in this understudied heart failure subgroup.
Source : https://pubmed.ncbi.nlm.nih.gov/38546848/
A role for inflammation in the development and progression of heart failure (HF) has been proposed for decades. Multiple studies have demonstrated the potential involvement of several groups of cytokines...
This review explores the role of inflammation in heart failure (HF) across ejection fraction phenotypes, focusing on biomarkers, immune pathways, and the potential of targeting inflammation in existing and future HF therapies.
Source : https://pubmed.ncbi.nlm.nih.gov/39117958/
Increased sympathetic and reduced parasympathetic nerve activity is associated with disease progression and poor outcomes in patients with chronic heart failure. The demonstration that markers of autonomic imbalance and vagal...
In chronic heart failure, increased sympathetic and reduced parasympathetic activity worsen outcomes. This review explores the role of parasympathetic dysfunction, assessment methods, and the potential of parasympathetic stimulation therapies.
Source : https://pubmed.ncbi.nlm.nih.gov/38431769/
BACKGROUND Idiopathic giant cell myocarditis (IGCM) is an uncommon and frequently fatal type of myocarditis. It primarily affects young individuals and has the potential to result in heart failure and...
A 65-year-old woman with refractory heart failure was diagnosed with idiopathic giant cell myocarditis (IGCM) after biopsy. Despite immunosuppressive treatment and ICD placement, she ultimately died due to disease complications.
Source : https://pubmed.ncbi.nlm.nih.gov/39512547/
The coexistence of heart failure (HF) and type 2 diabetes mellitus (T2DM) is common and poses a serious threat to human health because these diseases have a high degree of...
Coexistence of heart failure (HF) and type 2 diabetes (T2DM) is common but challenging to diagnose in primary care. Overlapping symptoms, like breathlessness and leg edema, complicate accurate HFpEF diagnosis and management.
Source : https://pubmed.ncbi.nlm.nih.gov/38224293/
Congenital tricuspid valve stenosis is extremely rare. We describe 2 cases of patients with adult congenital heart disease with hypoplastic tricuspid valve annulus who were symptomatic from annular- and leaflet-level...
Two adult congenital heart disease patients with hypoplastic tricuspid valve annulus and stenosis underwent successful transcatheter balloon valvuloplasty, offering a reasonable first-line treatment or bridge to valve replacement.
Source : https://pubmed.ncbi.nlm.nih.gov/38828236/
Blood-filled cysts of the heart valves are frequently reported at postpartum autopsies of infants. They are seen as round nodules mostly in the paediatric age group in infants less than...
This case report describes an 11-month-old girl with a blood-filled cyst on the pulmonary valve, successfully treated. It highlights the need for further research on diagnosis and treatment in pediatric patients.
Source : https://pubmed.ncbi.nlm.nih.gov/38885303/
Myocardial infarction is a cardiovascular disease characterized by a high incidence rate and mortality. It leads to various cardiac pathophysiological changes, including ischemia/reperfusion injury, inflammation, fibrosis, and ventricular remodeling, which...
Cardiac patches, using advanced scaffolds and delivery strategies, show promise for treating myocardial infarction by addressing ischemia, inflammation, and fibrosis, promoting cardiac repair, and overcoming limitations of current therapies.
Source : https://pubmed.ncbi.nlm.nih.gov/38927607/
Cardiac remodeling and ventricular pacing represent intertwined phenomena with profound implications for cardiovascular health and therapeutic interventions. This review explores the intricate relationship between cardiac remodeling and ventricular pacing, spanning...
This review examines the molecular and biomechanical interplay between cardiac remodeling and ventricular pacing, highlighting mechanisms, clinical implications, and strategies to optimize patient outcomes in cardiovascular care.
The Transformative Care Continuum (TCC) integrates a 3-year medical track with family medicine residency, emphasizing communication, leadership, and community care. Graduates excel in team dynamics and quality projects, driving health systems improvements. Challenges include scalability and ensuring sustained educational support.
Source : https://pubmed.ncbi.nlm.nih.gov/37837495/
Diastolic heart failure (DHF), in which impaired ventricular filling leads to typical heart failure symptoms, represents over 50% of all heart failure cases and is linked with risk factors, including...
Diastolic heart failure (DHF) involves impaired ventricular filling despite preserved systolic function. Exploring its molecular mechanisms can address knowledge gaps, highlight determinants of diastolic dysfunction, and guide novel therapeutic strategies.
Source : https://pubmed.ncbi.nlm.nih.gov/38133147/
In individuals diagnosed with chronic CHD and preserved LV EF, the initial invasive approach did not demonstrate a clinical advantage over OMT. Conversely, in patients with ischemic LV systolic dysfunction,...
In chronic CHD, invasive strategies offer no advantage over OMT for preserved LV function but improve survival and reduce CV events in patients with ischemic LV systolic dysfunction.
Did you know? Parallelizing diagnostic processes can significantly shorten production timelines, benefiting both patients and healthcare professionals. Faster diagnoses lead to earlier treatment initiation, reducing uncertainty and improving patient outcomes. Additionally, quicker treatment times result in faster recovery, making the entire care pathway more efficient for everyone involved.
How can streamlining diagnostic processes further improve patient recovery times and enhance the efficiency of healthcare teams?
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How can streamlining diagnostic processes further improve patient recovery times and enhance the efficiency of healthcare teams?
Initial Complaints: A 54-year-old male, presented with fatigue, mild shortness of breath, and occasional ankle swelling.
Brief History: His medical history includes well-controlled type 2 diabetes mellitus (T2D), hypertension, and obesity (BMI 32 kg/m²). He has no prior history of coronary artery disease or myocardial infarction, but both parents had heart disease.
Clinical Examination: Physical examination revealed bilateral ankle edema, jugular venous distension, and slightly elevated blood pressure (140/90 mmHg).
His weight was 110 kg, and heart sounds were regular with no murmurs. Symptoms included shortness of breath on exertion, likely exacerbated by obesity.
Diagnostic Workup: Echocardiography showed preserved left ventricular ejection fraction (LVEF) of 68%, indicating normal pump function. However, global longitudinal strain (GLS) was -16%, suggesting subclinical left ventricular dysfunction likely due to long-standing hypertension, diabetes, and obesity.
Laboratory Results: Routine blood tests indicated HbA1c at 6.8%. Kidney function was normal (eGFR 72 mL/min/1.73 m²). N-terminal pro-brain natriuretic peptide (NT-proBNP) levels were slightly elevated, indicating cardiac stress. The lipid panel revealed elevated triglycerides and borderline high LDL cholesterol.
At the American Heart Association’s centennial conference, Dr. Amit Khera, Director of Preventive Cardiology and Professor at UT Southwestern Medical Center, and Dr. John L. Sapp, Assistant Dean of Clinical Research at Dalhousie University, presented key findings. Topics included Tirzepatide’s impact on HFpEF and obesity, the comparison of left atrial appendage closure versus anticoagulation for atrial fibrillation, intensive blood pressure control in diabetes, and insights from the VANISH2 trial on ventricular tachycardia. These findings provide healthcare professionals with evidence-based strategies to advance cardiovascular care.
Source : https://pubmed.ncbi.nlm.nih.gov/38138216/
Atrial fibrillation (AF) and acute heart failure (AHF) are two closely interrelated conditions that frequently coexist in a manifold manner, with AF serving either as the causative factor or as...
Atrial fibrillation (AF) and acute heart failure (AHF) are interlinked conditions with shared pathways. Effective emergency management involves acute rate/rhythm control, anticoagulation, and addressing symptoms to break the worsening cycle.
Source : https://pubmed.ncbi.nlm.nih.gov/38994825/
The diagnosis of end-stage renal disease (ESRD) is made when the estimated glomerular filtration rate is less than 15 mL/min/1.73 m2. Most patients with that stage of chronic kidney disease...
End-stage renal disease increases cardiovascular risk, with heart failure and arrhythmias prevalent. This review explores natriuretic peptides and biomarkers in hemodialysis patients for assessing cardiovascular risk.
