Mitochondrial Structure and Function in Human Heart Failure - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38963864/
Despite clinical and scientific advancements, heart failure is the major cause of morbidity and mortality worldwide. Both mitochondrial dysfunction and inflammation contribute to the development and progression of heart failure....
This review explores mitochondrial dysfunction and inflammation in heart failure, focusing on mitochondrial dynamics, ultrastructure changes, and therapeutic targets to improve cardiac function and energy metabolism.
Impact of empagliflozin on insulin needs in patients with heart failure and diabetes: An EMPEROR-Pooled analysis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38558314/
Empagliflozin exerts a consistent benefit on cardiovascular outcomes and renal function decline, irrespective of baseline insulin use, and reduces the need for sustained insulin initiation in patients with HF and...
Empagliflozin benefits cardiovascular outcomes and renal function in heart failure patients with diabetes, regardless of baseline insulin use, and reduces the need for sustained insulin initiation in non-insulin users.
Novel Prediction Equations for Absolute Risk Assessment of Total Cardiovascular Disease Incorporating Cardiovascular-Kidney-Metabolic Health: A Scientific Statement From the American Heart Association - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37947094/
Cardiovascular-kidney-metabolic (CKM) syndrome is a novel construct recently defined by the American Heart Association in response to the high prevalence of metabolic and kidney disease. Epidemiological data demonstrate higher absolute...
The PREVENT equations assess 10- and 30-year cardiovascular disease risk, incorporating CKM syndrome predictors, kidney function, and social determinants of health to enhance primary prevention strategies for diverse populations.
Summary and Comparison of the 2022 ACC/AHA/HFSA and 2021 ESC Heart Failure Guidelines - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37653361/
The guidelines released by the American College of Cardiology/American Heart Association/Heart Failure Society of America (ACC/AHA/HFSA) in 2022 and those released in 2021 by the European Society of Cardiology (ESC)...
The 2022 ACC/AHA/HFSA and 2021 ESC guidelines for heart failure align on key recommendations but differ due to timing; this review highlights differences to support evidence-based clinical decision-making.
Distinct Comorbidity Clusters in Patients With Acute Heart Failure: Data From RELAX-AHF-2 - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38970586/
Comorbidities naturally clustered into 5 mutually exclusive groups in RELAX-AHF-2, showing variations in clinical outcomes. These data emphasize that the specific combination of comorbidities can influence adverse outcomes and treatment...
The study identified five multimorbidity groups in acute heart failure patients, highlighting distinct clinical outcomes and treatment responses, emphasizing the importance of comorbidity patterns in managing these patients.