Interatrial Shunt Treatment for Heart Failure: The Randomized RELIEVE-HF Trial - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39308371/
URL: https://www.clinicaltrials.gov; Unique identifier: NCT03499236.
Interatrial shunt implantation was safe in HF patients but showed benefit only in reduced LVEF, while worsening outcomes in preserved LVEF.
Consequences of Discontinuing Long-Term Drug Treatment in Patients With Heart Failure and Reduced Ejection Fraction - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39453366/
There is uncertainty regarding the clinical effects of discontinuation of drugs for heart failure after long-term use. The withdrawal of long-term treatment can follow 1 of 4 distinct patterns: 1)...
Heart failure drug withdrawal often leads to clinical deterioration, with varied persistence of effects across agents. Evidence underscores avoiding treatment gaps and maintaining foundational therapies for optimal outcomes.
Cardiac Fibrosis in the Multi-Omics Era: Implications for Heart Failure - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/40146800/
Cardiac fibrosis, a hallmark of heart failure and various cardiomyopathies, represents a complex pathological process that has long challenged therapeutic intervention. High-throughput omics technologies have begun revolutionizing our understanding of...
Multi-omics technologies unravel genetic, epigenetic, transcriptomic, proteomic, and metabolic mechanisms of cardiac fibrosis, revealing fibroblast heterogeneity, biomarkers, and therapeutic targets, driving precision medicine and personalized strategies for heart failure and cardiomyopathies.
Heart failure, inflammation and exercise - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/40520009/
Heart failure (HF) is a condition characterized by high morbidity, mortality, and a substantial healthcare burden, in which inflammation plays a pivotal role. This review provides a comprehensive overview of...
This review highlights inflammation’s central role in heart failure progression, discussing immune alterations, biomarkers, and signaling pathways, while emphasizing exercise’s therapeutic potential through anti-inflammatory modulation and personalized intervention strategies.
State of precision medicine for heart failure with preserved ejection fraction in a new therapeutic age - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39844745/
Heart failure with preserved ejection fraction (HFpEF) is defined by heart failure (HF) with a left ventricular ejection fraction (LVEF) of at least 50%. HFpEF has a complex and heterogeneous...
HFpEF is a complex, heterogeneous condition challenging to diagnose. Algorithms (H2FPEF, HFA-PEFF), phenotype clustering, and SGLT2 inhibitors aid management, while future research explores precision diagnostics and novel therapies.