Effect of Empagliflozin on Heart Failure Outcomes After Acute Myocardial Infarction: Insights From the EMPACT-MI Trial
Source : https://pubmed.ncbi.nlm.nih.gov/38581389/
URL: https://www.clinicaltrials.gov; Unique identifier: NCT04509674.
Empagliflozin reduced the risk of HF in patients with left ventricular dysfunction or congestion after acute myocardial infarction.
2024 update in heart failure
Source : https://pubmed.ncbi.nlm.nih.gov/38806171/
In the last years, major progress has occurred in heart failure (HF) management. The 2023 ESC focused update of the 2021 HF guidelines introduced new key recommendations based on the...
Recent updates in heart failure management highlight significant advances such as the use of SGLT2 inhibitors and finerenone for prevention in diabetic CKD, and expanded treatments across HF spectrums. Emerging therapies like vericiguat and semaglutide show promise, while ongoing research continues to refine treatment strategies.
Heart Rate Recovery: Up to Date in Heart Failure-A Literature Review
Source : https://pubmed.ncbi.nlm.nih.gov/38893039/
The rising prevalence of cardiovascular disease underscores the growing significance of heart failure (HF). Pathophysiological insights into HF highlight the dysregulation of the autonomic nervous system (ANS), characterized by sympathetic...
This study highlights the importance of heart rate recovery (HRR) in cardiovascular assessments and the need for standardized evaluation protocols, especially in heart failure, to improve diagnostics and patient care.
Blood pressure and heart failure: focused on treatment
Source : https://pubmed.ncbi.nlm.nih.gov/38822445/
Heart failure (HF) remains a significant global health burden, and hypertension is known to be the primary contributor to its development. Although aggressive hypertension treatment can prevent heart changes in...
Addressing low BP in HF patients is complex, requiring individualized treatment strategies based on patient conditions, comorbidities, and HF etiology, as a one-size-fits-all approach is ineffective.
Targeting cardiomyocyte cell cycle regulation in heart failure
Source : https://pubmed.ncbi.nlm.nih.gov/38683371/
Heart failure continues to be a significant global health concern, causing substantial morbidity and mortality. The limited ability of the adult heart to regenerate has posed challenges in finding effective...
The massive loss of cardiomyocytes after cardiac injury and their subsequent replacement by fibrotic tissue is the major cause of heart failure, while the cardiomyocytes have limited proliferative capacity. Therefore, inducing resident cardiomyocytes to re-enter the cell cycle and progress through mitosis and cytokinesis is the most...