Uric acid and sodium-glucose cotransporter-2 inhibition with empagliflozin in heart failure with reduced ejection fraction: the EMPEROR-reduced trial - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35788657/
Hyperuricaemia is common in HF and is an independent predictor of advanced disease severity and increased mortality. Empagliflozin induced a rapid and sustained reduction of SUA levels and of clinical...
Conclusion: Hyperuricaemia is common in HF and is an independent predictor of advanced disease severity and increased mortality. Empagliflozin induced a rapid and sustained reduction of SUA levels and of clinical events related to hyperuricaemia. The benefit of empagliflozin on the primary outcome was observed independently of SUA.
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Winner Winner Turkey Dinner! An Empirical Approach to Measuring Palatability and Satisfaction with Emergency Department Turkey Sandwiches
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213106/
Despite their popularity in many EDs, little is known regarding perceptions of turkey sandwiches among patients. Given the importance of turkey sandwiches as a form of nutrition provided in EDs,...
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Mild and moderate to severe early acute kidney injury following cardiac surgery among patients with heart failure and preserved vs. mid-range vs. reduced ejection fraction: A retrospective cohort study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35791895/
doi: 10.1097/EJA.0000000000001713. Online ahead of print. 1 From the Department of Anaesthesiology (YG, CW, JL, JW, FY), Department of Cardiopulmonary Bypass (BJ), Fuwai Hospital, National Centre for Cardiovascular Diseases, Chinese...
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Current updates in the pharmacotherapy of heart failure with a preserved ejection fraction
Source : https://www.eurekaselect.com/article/124935
Background: Heart failure is the leading cause of morbidity and mortality worldwide. With improved longevity, the incidence and prevalence of heart failure continue to rise with an estimated prevalence of...
Conclusion: EMPEROR-PRESERVED (Empagliflozin) and PRESERVED-HF (Dapagliflozin) results in the management of HFpEF look promising irrespective of diabetes status. Sacubitril-valsartan and Empagliflozon are the only medications approved for its management as per the PARAGON-HF and EMPEROR-PRESERVED studies respectively.
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The future of heart failure with preserved ejection fraction : Deep phenotyping for targeted therapeutics - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35767073/
Heart failure (HF) with preserved ejection fraction (HFpEF) is a multi-organ, systemic syndrome that involves multiple cardiac and extracardiac pathophysiologic abnormalities. Because HFpEF is a heterogeneous syndrome and resistant to...
Relevance: Here we provide a framework for understanding the phenotype-based approach to HFpEF by reviewing (1) the historical context of HFpEF; (2) the current HFpEF paradigm of comorbidity-induced inflammation and endothelial dysfunction; (3) various methods of sub-phenotyping HFpEF; (4) comorbidity-based classification and treatment of...
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Heart Failure Connect3yrKey Points • Source: Herz • Relevance: “Here we provide a framework for understanding the phenotype-based approach to HFpEF by reviewing (1) the historical context of HFpEF; (2) the current HFpEF paradigm of comorbidity-induced Show More