Numerous mechanisms likely underlie the cardioprotective effects of SGLT2. The following excerpt from JACC: Basic to Translational Science outlines them as follows:
“These include beneficial effects of SGLT2 inhibition on the following: 1) blood pressure lowering; 2) increasing diuresis/natriuresis; 3) improving cardiac energy metabolism; 4) preventing inflammation; 5) weight loss; 6) improving glucose control; 7) inhibiting the sympathetic nervous system; 8) preventing adverse cardiac remodeling; 9) preventing ischemia/reperfusion injury; 10) inhibiting the cardiac Na+/H+ exchanger; 11) inhibiting SGLT1; 12) reducing hyperuricemia; 13) increasing autophagy and lysosomal degradation; 14) decreasing epicardial fat mass; 15) increasing erythropoietin (EPO) levels; 16) increasing circulating provascular progenitor cells; 17) decreasing oxidative stress; and 18) improving vascular function.”
If interested, please refer to the rest of the article for a more detailed analysis:
Recent clinical trials have shown that sodium glucose co-transport 2 (SGLT2) inhibitors have dramatic beneficial cardiovascular outcomes. These include a reduced incidence of cardiovascular death and heart failure hospitalization in people with and without ...
Numerous mechanisms likely underlie the cardioprotective effects of SGLT2. The following excerpt from JACC: Basic to Translational Science outlines them as follows:
“These include beneficial effects of SGLT2 inhibition on the following: 1) blood pressure lowering; 2) increasing diuresis/natriuresis; 3) improving cardiac energy metabolism; 4) preventing inflammation; 5) weight loss; 6) improving glucose control; 7) inhibiting the sympathetic nervous system; 8) preventing adverse cardiac remodeling; 9) preventing ischemia/reperfusion injury; 10) inhibiting the cardiac Na+/H+ exchanger; 11) inhibiting SGLT1; 12) reducing hyperuricemia; 13) increasing autophagy and lysosomal degradation; 14) decreasing epicardial fat mass; 15) increasing erythropoietin (EPO) levels; 16) increasing circulating provascular progenitor cells; 17) decreasing oxidative stress; and 18) improving vascular function.”
If interested, please refer to the rest of the article for a more detailed analysis:
Mechanisms of Cardiovascular Benefits of Sodium Glucose Co-Transporter 2 (SGLT2) Inhibitors: A State-of-the-Art Review
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315190/
Recent clinical trials have shown that sodium glucose co-transport 2 (SGLT2) inhibitors have dramatic beneficial cardiovascular outcomes. These include a reduced incidence of cardiovascular death and heart failure hospitalization in people with and without ...