Symptomatic aortitis at giant cell arteritis diagnosis: a prognostic factor of aortic event

Source : https://arthritis-research.biomedcentral.com/articles/10.1186/s13075-020-02396-5

Giant cell arteritis (GCA) is frequently associated with aortic involvement that is likely to cause life-threatening structural complications (aneurysm, dissection). Few studies have investigated the occurrence of these complications, and...

A Polygenic Score for Type 2 Diabetes Risk Is Associated With Both the Acute and Sustained Response to Sulfonylureas

Source : https://diabetes.diabetesjournals.org/content/70/1/293

There is a limited understanding of how genetic loci associated with glycemic traits and type 2 diabetes (T2D) influence the response to antidiabetic medications. Polygenic scores provide increasing power to...

Depletion of Adipocyte Becn1 Leads to Lipodystrophy and Metabolic Dysregulation

Source : https://diabetes.diabetesjournals.org/content/70/1/182

Becn1 / Beclin-1 is a core component of the class III phosphatidylinositol 3-kinase required for autophagosome formation and vesicular trafficking. Although Becn1 has been implicated in numerous diseases such as...

Advanced Liver Fibrosis Is Common in Patients With Type 2 Diabetes Followed in the Outpatient Setting: The Need for Systematic Screening

Source : https://care.diabetesjournals.org/content/early/2020/12/15/dc20-1997.full

OBJECTIVE Assess the prevalence of nonalcoholic fatty liver disease (NAFLD) and of liver fibrosis associated with nonalcoholic steatohepatitis in unselected patients with type 2 diabetes mellitus (T2DM). RESEARCH DESIGN AND...

Serum Vitamin D Affected Type 2 Diabetes though Altering Lipid Profile and Modified the Effects of Testosterone on Diabetes Status

Source : https://www.mdpi.com/2072-6643/13/1/90

Numerous studies have investigated the associations between serum vitamin D or testosterone and diabetes; however, inconsistencies are observed. Whether there is an interaction between vitamin D and testosterone and whether...