Dose-response effects on HbA1c and bodyweight reduction of survodutide, a dual glucagon/GLP-1 receptor agonist, compared with placebo and open-label semaglutide in people with type 2 diabetes: a randomised clinical trial
Source : https://pubmed.ncbi.nlm.nih.gov/38095657/
Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim, Germany.
Survodutide effectively reduced HbA1c and bodyweight in type 2 diabetes patients over 16 weeks, with greater bodyweight loss compared to semaglutide; gastrointestinal AEs were dose-related.
Recent advances in the treatment of type 2 diabetes mellitus using new drug therapies
Source : https://pubmed.ncbi.nlm.nih.gov/38183334/
Several recent advances provide multiple health benefits to individuals with type 2 diabetes mellitus (T2DM). Pharmacological therapy is governed by person-centered factors, including comorbidities and treatment goals. Adults with T2DM...
Recent advances in pharmacological management of T2DM emphasize integrated therapies focusing on cardiorenal protection, weight management, and improved glycemic control, including new dual agonists and emerging treatments.
Prevention of type 2 diabetes and its complications
Source : https://pubmed.ncbi.nlm.nih.gov/38869130/
Type 2 diabetes (T2D) represents a major medical and public health problem. The ability to prevent or delay T2D by modifying some of its risk factors has been hypothesized for...
In overweight or obese adults at high risk of developing type 2 diabetes, interventions such as weight loss strategies (including bariatric surgery), increased physical activity, and pharmacotherapy (e.g., metformin) can significantly delay onset and improve outcomes.
Selenium Species in Diabetes Mellitus Type 2
Source : https://pubmed.ncbi.nlm.nih.gov/37880477/
Selenium is an important trace element for humans and animals as it plays a key role in several major metabolic pathways. Several studies were conducted to better understand the role...
Recent studies on selenium and diabetes mellitus (DM), particularly type 2 (T2DM), reveal a complex relationship. Selenium's impact isn't linear but dose-dependent, often exhibiting a U-shaped curve influenced by chemical forms in diet or supplements. Optimal intake, considering baseline selenium levels, is crucial to mitigate diabetes risk.
Surveillance of the liver in type 2 diabetes: important but unfeasible
Source : https://pubmed.ncbi.nlm.nih.gov/38334817/
Fatty liver plays a pivotal role in the pathogenesis of the metabolic syndrome and type 2 diabetes. According to an updated classification, any individual with liver steatosis and one or...
Early detection of metabolic dysfunction-associated steatotic liver disease (MASLD) in type 2 diabetes is crucial, emphasizing the need for more accurate screening strategies and effective management through weight loss interventions and emerging fibrosis biomarkers.