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3yr
Comparison of Beneficial Metabolic Effects of Liraglutide and Semaglutide in Male C57BL/6J Mice

Comparison of Beneficial Metabolic Effects of Liraglutide and Semaglutide in Male C57BL/6J Mice

Source : https://www.canadianjournalofdiabetes.com/article/S1499-2671(21)00232-X/fulltext

Semaglutide and liraglutide are glucagon-like peptide-1 (GLP-1)-based diabetes drugs. Semaglutide possesses a longer half-life. Utilizing relatively lower doses, we compared the beneficial metabolic effects of these 2 drugs in mice...



Conclusions: Liraglutide, but not semaglutide, increased hepatic FGF21 protein level, whereas semaglutide had a greater effect on attenuating hyperleptinemia. Thus, these 2 GLP-1–based diabetes drugs may target metabolic organs, including liver and adipose tissue, with differing levels of efficacy.


  • 3yr
    Article mentions that HD semaglutide showed an even better effect on attenuating hyperleptinemia
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3yr

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Effects of Semaglutide on Stroke Subtypes in Type 2 Diabetes: Post Hoc Analysis of the Randomized SUSTAIN 6 and PIONEER 6

Source : https://www.ahajournals.org/doi/10.1161/STROKEAHA.121.037775?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub

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3yr
The Cost-Effectiveness of Oral Semaglutide in Spain: A Long-Term Health Economic Analysis Based on the PIONEER Clinical Trials - PubMed

The Cost-Effectiveness of Oral Semaglutide in Spain: A Long-Term Health Economic Analysis Based on the PIONEER Clinical Trials - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/35553372/

doi: 10.1007/s12325-022-02156-8. Online ahead of print. 1 Centro de Investigación Biomédica en Red en Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain. 2 Primary Health Care Center Raval Sud, Gerència...



Conclusion: Oral semaglutide 14 mg was dominant versus sitagliptin and liraglutide, and cost-effective versus empagliflozin, for the treatment of type 2 diabetes in Spain.

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3yr
Oral Semaglutide: Dosage in Special Situations - Diabetes Therapy

Oral Semaglutide: Dosage in Special Situations - Diabetes Therapy

Source : https://link.springer.com/article/10.1007/s13300-022-01265-5

Glucagon-like peptide 1 receptor agonists (GLP1RAs) have recently gained momentum after the introduction of semaglutide, the first oral molecule in their class. In a recent article in this journal by...



Relevance: Special emphasis is laid on the use of oral semaglutide in persons already on injectable GLP-1RA formulations, those experiencing sudden changes in life style pattern due to religious, social, or professional commitments, individuals seeking help for urgent glycemic control, and those who face sudden change in their concomitant...

  • 3yr
    Key Points • Source: Diabetes Therapy • Relevance: “This commentary, based on the expert opinion of the authors and suggestions mentioned in other peer-reviewed published papers, shares clinical tips on how to use the Show More
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3yr
Dose-dependent effect of carbohydrate restriction for type 2 diabetes management: a systematic review and dose-response meta-analysis of randomized controlled trials - PubMed

Dose-dependent effect of carbohydrate restriction for type 2 diabetes management: a systematic review and dose-response meta-analysis of randomized controlled trials - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/35537861/

Carbohydrate restriction can exert a significant and important reduction on levels of cardiometabolic risk factors in patients with type 2 diabetes. Levels of most cardiometabolic outcomes decreased linearly with the...


Conclusions: Carbohydrate restriction can exert a significant and important reduction on levels of cardiometabolic risk factors in patients with type 2 diabetes. Levels of most cardiometabolic outcomes decreased linearly with the decrease in carbohydrate intake. U-shaped effects were seen for total cholesterol and LDL cholesterol at 6 months...