Semaglutide reduces cardiovascular events regardless of metformin use: a post hoc subgroup analysis of SUSTAIN 6 and PIONEER 6 - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35484580/
doi: 10.1186/s12933-022-01489-6. 1 Ted Rogers Centre for Heart Research, Department of Medicine, University of Toronto, Peter Munk Cardiac Centre, Toronto General Hospital, 200 Elizabeth St, PMCRT 3-904, M5G2C4, Toronto, Canada....
Conclusions: Our study implies that Liraglutide protects the cardiac, cerebral and renal microvasculature against diabetes-induced dysfunction, independent of lowering blood glucose in a type 1 diabetes rat model.
Exenatide Once Weekly for Management of Type 2 Diabetes: A Review
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9004502/
Clin Pharmacol. 2022; 14: 19-26. Exenatide is one of the exendin-based glucagon-like peptide 1 receptor agonists (GLP-1RAs) and is currently available in two formulations, ie, exenatide twice daily (BID), a...
Conclusions: This review provides an overview of the current evidence regarding the clinical efficacy and safety of exenatide QW and discusses the current perspectives on exenatide QW for treatment of T2DM.
Glucagon-like Peptide-1 Receptor Agonists in the Management of Type 2 Diabetes Mellitus and Obesity: The Impact of Pharmacological Properties and Genetic Factors - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35408810/
1 Department of Abdominal Surgery, Division of Surgery, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia. 2 Pharmacogenetics Laboratory, Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana,...
Conclusion/Relevance: This review focuses on the pharmacological, clinical, and genetic factors that may influence the response to GLP-1 receptor agonists in the treatment of type 2 diabetes mellitus and obesity.
Comparison of the Effectiveness of Liraglutide vs Semaglutide in a Veteran Population - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35414304/
Background: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are commonly prescribed medications for patients with type 2 diabetes mellitus (T2DM) based on cardiovascular benefits. Objective: This study aimed to evaluate efficacy...
Conclusion: The results of this study indicate no difference between liraglutide and semaglutide in terms of A1c-lowering potential, but it provides insights into key considerations for the Veteran population.
Safety and efficacy of combination therapy with semaglutide, cilofexor and firsocostat in patients with non-alcoholic steatohepatitis: A randomised, open-label phase II trial
Source : https://www.journal-of-hepatology.eu/article/S0168-8278(22)00235-5/fulltext
Non-alcoholic steatohepatitis (NASH) is associated with increased risk of liver-related and cardiovascular morbidity and mortality. Given the complex pathophysiology of NASH, combining therapies with complementary mechanisms may be beneficial. This...
Conclusions: In patients with mild-to-moderate fibrosis due to NASH, semaglutide with firsocostat and/or cilofexor was generally well tolerated. In exploratory efficacy analyses, treatment resulted in additional improvements in liver steatosis and biochemistry vs. semaglutide alone. Given this was a small-scale open-label trial, double-blind...
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