Glucolipotoxicity promotes the capacity of the glycerolipid/NEFA cycle supporting the secretory response of pancreatic beta cells - Diabetologia
Source : https://link.springer.com/article/10.1007/s00125-021-05633-x
Aims/hypothesis Chronic exposure of pancreatic beta cells to high glucose and fatty acids has been proposed to induce glucolipotoxicity. However, contradictory results suggest adaptations of the beta cells, which might...
Conclusions/Interpretation: "Glucolipotoxic conditions promote the capacity of the glycerolipid/NEFA cycle thereby preserving part of the secretory response. The cycle of fat storage/mobilisation emerges as a mechanism helping the beta cell to cope with glucotoxic conditions.
Combined SGLT-2 and ACE inhibition upregulates the renin-angiotensin system in chronic kidney disease with type 2 diabetes: Results of a randomized, double-blind, placebo-controlled exploratory trial - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34984822/
Aims: Sodium glucose co-transporter-2 inhibitors (SGLT-2i) improve cardiorenal outcomes in chronic kidney disease (CKD) patients with and without type 2 diabetes. The molecular mechanisms underlying these pleiotropic effects remain unclear,...
Conclusion: "A distinct RAS modulation by SGLT-2i occurs in diabetic kidney disease reflected by enhancement of the beneficial Angiotensin-(1–7) providing a molecular background for this renoprotective therapeutic approach."
Effects of a six-month low-carbohydrate diet on glycemic control, body composition and cardiovascular risk factors in patients with type 2 diabetes: an open-label RCT - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34984805/
A non-calorie-restricted LCD high in fat has significant beneficial effects on glycemic control and body composition, and does not adversely affect cardiovascular risk factors in patients with T2D. Reducing carbohydrate...
Conclusion: A non-calorie-restricted LCD high in fat has significant beneficial effects on glycemic control and body composition, and does not adversely affect cardiovascular risk factors in patients with T2D. Reducing carbohydrate intake to 10-25 E% seems an effective and safe nutritional approach with respect to classical cardiovascular risk...
PIEZO1 mediates a mechanothrombotic pathway in diabetes
Source : https://www.science.org/doi/10.1126/scitranslmed.abk1707
Patients with diabetes are at increased risk of thrombosis. Zhu et al. show that the mechanosensitive ion channel PIEZO1 is dysregulated in hematopoietic lineage cells during hyperglycemia. The increased PIEZO1...
Our findings identify a candidate target to precisely modulate mechanically induced thrombosis in T2DM and a potential screening method to predict patient-specific risk. Ongoing remodeling of cell lineages in hematopoiesis is an integral component of thrombotic risk in T2DM, and related mechanisms may have a broader role in chronic disease.
A healthy dietary pattern with a low inflammatory potential reduces the risk of gestational diabetes mellitus - European Journal of Nutrition
Source : https://link.springer.com/article/10.1007/s00394-021-02749-z
Purpose An optimal diet for lowering the risk of gestational diabetes mellitus (GDM) is still to be defined, but may comprise of nutrient intakes, dietary patterns, diet quality, and eating...
Conclusions: "The results emphasize the importance of an overall healthy diet and limitation of foods with SFAs, and other nutrients with a high inflammatory potential in reducing the risk of GDM.
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