Efficacy of Off-Label Therapy for Non-alcoholic Fatty Liver Disease in Improving Non-invasive and Invasive Biomarkers: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35280867/
doi: 10.3389/fmed.2022.793203. 1 Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China. 2 Key Laboratory of Chinese Internal Medicine of Ministry of Education...
Conclusion: The network meta-analysis provided evidence for the efficacy of vitamin E, pioglitazone, SGLT2 inhibitors, and GLP-1 receptor agonists in treating patients with NAFLD. To find the best guide-level drugs, it is necessary to include more RCTs with these off-label drugs, so that patients and clinicians can make optimal decisions...
Secular trends in global burden of diabetes attributable to particulate matter pollution from 1990 to 2019 - Environmental Science and Pollution Research
Source : https://link.springer.com/article/10.1007/s11356-022-19510-6
Increasing evidence suggests an association between fine particulate matter (PM2.5) exposure and type 2 diabetes mellitus. However, there is still a lack of comparative evaluation regarding diabetes burden due to...
Conclusion/Relevance: The elderly and people in low-SDI countries suffered from the greatest burden of diabetes due to PM2.5 pollution. More targeted interventions should be taken by governments to reduce PM2.5 exposure and related diabetes burden.
Effect of Oral Semaglutide on Cardiovascular Parameters and Their Mechanisms in Patients with Type 2 Diabetes: Rationale and Design of the Semaglutide Anti-Atherosclerotic Mechanisms of Action Study (SAMAS) - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35258841/
doi: 10.1007/s13300-022-01226-y. Online ahead of print. 1 Clinical Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Centre Ljubljana, Zaloška 7, 1000, Ljubljana, Slovenia. [email protected]. 2 Medical Faculty, University of...
Discussion: This is the first study to investigate the direct and indirect anti-atherosclerotic mechanisms of oral semaglutide. The results are expected to confirm the position of oral semaglutide in the multifactorial management of T2D with an emphasis on cardiovascular disease prevention.
Greater Adherence and Persistence with Injectable Dulaglutide Compared with Injectable Semaglutide at 1-Year Follow-up: Data from US Clinical Practice
Source : https://www.clinicaltherapeutics.com/article/S0149-2918(22)00052-2/fulltext
Greater medication adherence and persistence have been associated with improved glycemic control in patients with type 2 diabetes mellitus. This study compared adherence, persistence, and treatment patterns among patients naïve...
Implications: At both 6M and 12M follow-up, dulaglutide initiators had significantly greater adherence and greater persistence compared with matched semaglutide initiators.
Adverse drug reactions of GLP-1 agonists: A systematic review of case reports
Source : https://www.sciencedirect.com/science/article/abs/pii/S1871402122000418?via=ihub
GLP-1 receptor agonists are most commonly associated with gastrointestinal problems, particularly pancreatitis. * Exenatide and liraglutide caused maximum ADRs, whereas albiglutide and lixisenatide caused minimum ADRs. * Renal, dermatologic, hematologic,...
Conclusion: Gastrointestinal problems, particularly pancreatitis was the more frequently reported adverse drug reaction associated with GLP-1 agonist. The most adverse drug reactions were observed with liraglutide and exenatide.