Facile Photolithographic Fabrication of Zwitterionic Polymer Microneedles with Protein Aggregation Inhibition for Transdermal Drug Delivery
Source : https://pubs.acs.org/doi/10.1021/acs.biomac.1c01325
Microneedle technology has received considerable attention in transdermal drug delivery system research owing to its minimally invasive and convenient self-administration with enhanced transdermal transport. The pre-drug loading microneedle method has...
The microneedles exhibit a high drug loading capacity along with an efficient drug release rate. The rhodamine B drug loading and release model shows that the microneedles can load 8 μg of drugs on one microneedle patch of 41 needles and release nearly 80% of its load within 1 h. We anticipate that this pre-drug loading platform and the...
Early insulin-resistance, T2D and treatment options in childhood - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34915489/
Background T2D (Type 2 Diabetes) represents just the tip of the iceberg of the complex metabolic alterations associated with obesity and other clinical conditions associated to impaired adipose tissue storage....
"This review will focus on the main components defining the risk of IR and T2D in childhood with a specific focus on the main aspects of treatment options available in children and adolescents. Key messages Impaired adipose tissue storage documented in obesity results in a continuous spectrum of metabolic alterations ranging from IR to T2DM....
Effect of lifestyle intervention on the risk of incident diabetes in individuals with impaired fasting glucose and low or high genetic risk for the development of type 2 diabetes in men: a T2D-GENE trial - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34650392/
doi: 10.29219/fnr.v65.7721. 1 School of Medicine, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland. 2 Department of Medicine, Endocrinology and Clinical Nutrition, Kuopio University Hospital,...
Conclusion: If the effects of the lifestyle intervention are independent from the genetic risk of the participants, our study will be of great importance for the entire T2D research community, health care providers, and individuals at high risk for T2D. In this case, lifestyle intervention is beneficial for all individuals at risk for...
Association of healthy lifestyle including a healthy sleep pattern with incident type 2 diabetes mellitus among individuals with hypertension - Cardiovascular Diabetology
Source : https://cardiab.biomedcentral.com/articles/10.1186/s12933-021-01434-z
Background Evidence is limited regarding the association of healthy lifestyle including sleep pattern with the risk of complicated type 2 diabetes mellitus (T2DM) among patients with hypertension. We aimed to...
Conclusions: Adherence to a healthy lifestyle pattern including a healthy sleep pattern is associated with lower risk of T2DM in hypertensives, and this benefit is even further in normotension.
Heart rate-corrected QT interval: a novel diagnostic biomarker for diabetic peripheral neuropathy - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34932277/
doi: 10.1111/jdi.13738. Online ahead of print. 1 Department of Endocrinology, Nanjing Medical University, Nanjing First Hospital, Nanjing, Jiangsu Province, China. 2 Nanjing Medical University, Nanjing, Jiangsu Province, China. 3 Department...
Conclusions: QTc interval with 428.5ms has more reliable diagnostic utility for DPN than nerve conduction velocity, and prolonged QTc interval is closely associated with increased risk of DPN.