Greater Adherence and Persistence with Injectable Dulaglutide Compared with Injectable Semaglutide at 1-Year Follow-up: Data from US Clinical Practice
Source : https://www.clinicaltherapeutics.com/article/S0149-2918(22)00052-2/fulltext
Greater medication adherence and persistence have been associated with improved glycemic control in patients with type 2 diabetes mellitus. This study compared adherence, persistence, and treatment patterns among patients naïve...
Implications: At both 6M and 12M follow-up, dulaglutide initiators had significantly greater adherence and greater persistence compared with matched semaglutide initiators.
Adverse drug reactions of GLP-1 agonists: A systematic review of case reports
Source : https://www.sciencedirect.com/science/article/abs/pii/S1871402122000418?via=ihub
GLP-1 receptor agonists are most commonly associated with gastrointestinal problems, particularly pancreatitis. * Exenatide and liraglutide caused maximum ADRs, whereas albiglutide and lixisenatide caused minimum ADRs. * Renal, dermatologic, hematologic,...
Conclusion: Gastrointestinal problems, particularly pancreatitis was the more frequently reported adverse drug reaction associated with GLP-1 agonist. The most adverse drug reactions were observed with liraglutide and exenatide.
New practice in semaglutide on type-2 diabetes and obesity: clinical evidence and expectation - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35226299/
Obesity is an important risk factor of type 2 diabetes (T2D), which has become an important factor threatening human health. However, no perfect drug choice for obesity exists. Semaglutide is...
Relevance: This review summarizes clinical evidence of the semaglutide effect on T2D and obesity and establishes expectations on future clinical trials for obesity treatment.
Peptide-based long-acting co-agonists of GLP-1 and cholecystokinin 1 receptors as novel anti-diabesity agents
Source : https://www.sciencedirect.com/science/article/abs/pii/S0223523422001167?via=ihub
Novel GLP-1R/CCK-1R co-agonists derivatized from the peptide backbone of xGLP-1. * 2a and 2c exhibited potent and selective GLP-1R and CCK-1R activation potency. * 2a and 2c showed prominent hypoglycemic...
/>
Conclusion: These preclinical studies suggest that the pharmacological effects of CCK-1 and GLP-1 pathways can be harnessed in a single fusion peptide, yielding a promising combination therapy strategy for treating metabolic disorders.
The acceptability and effect of a culturally-tailored dance intervention to promote physical activity in women of South Asian origin at risk of diabetes in the Netherlands-A mixed-methods feasibility study
Source : https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0264191
Objective Populations of South Asian (SA) origin are at high risk of type 2 diabetes (T2D) and related complications. Analysis of T2D prevention interventions for these populations show that limited...
Conclusions: Bollywood Dance appears to be a feasible, culturally acceptable and potentially effective approach to increase PA in SA women in the Netherlands. A pilot cluster RCT is needed to confirm these initial findings on effectiveness.