Preoperative plasma aldosterone predicts complete remission of type 2 diabetes after bariatric surgery - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35016181/
Introduction: Bariatric surgery (BS) has beneficial effects on body weight and type 2 diabetes. However, 44-52%, 20-40%, and 19-25% of patients with type 2 diabetes who undergo sleeve gastrectomy, sleeve...
Discussion/Conclusion: Preoperative plasma aldosterone levels were related to the CR of type 2 diabetes after BS. Measuring plasma aldosterone levels preoperatively is useful for predicting the CR of type 2 diabetes after BS.
Decline in renal function associated with cardiovascular autonomic neuropathy positively coordinated with proteinuria in patients with type 2 diabetes - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34228899/
1 Department of Pharmacotherapy, Meiji Pharmaceutical University, Kiyose City, Japan. 2 Divisoin of Clinical Laboratory, The Institute for Medical Science, Asahi Life Foundation, Chuo-ku, Japan. 3 Department of Public Health...
Conclusion: "CAN strongly increased the risk of a 40% eGFR decline from baseline, especially in type 2 diabetes patients with macroproteinuria."
Low fasting glucose-to-estimated average glucose ratio was associated with superior response to insulin degludec/aspart compared with basal insulin in patients with type 2 diabetes - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34291584/
1 Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea. 2 Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul National University Bundang...
Conclusions: "We observed that IDegAsp was more effective than basal insulin in patients with an FPG lower than predicted by HbA1c, which might be related with insulin deficiency and postprandial hyperglycemia in patients on basal insulin therapy."
Glucolipotoxicity promotes the capacity of the glycerolipid/NEFA cycle supporting the secretory response of pancreatic beta cells - Diabetologia
Source : https://link.springer.com/article/10.1007/s00125-021-05633-x
Aims/hypothesis Chronic exposure of pancreatic beta cells to high glucose and fatty acids has been proposed to induce glucolipotoxicity. However, contradictory results suggest adaptations of the beta cells, which might...
Conclusions/Interpretation: "Glucolipotoxic conditions promote the capacity of the glycerolipid/NEFA cycle thereby preserving part of the secretory response. The cycle of fat storage/mobilisation emerges as a mechanism helping the beta cell to cope with glucotoxic conditions.
Combined SGLT-2 and ACE inhibition upregulates the renin-angiotensin system in chronic kidney disease with type 2 diabetes: Results of a randomized, double-blind, placebo-controlled exploratory trial - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34984822/
Aims: Sodium glucose co-transporter-2 inhibitors (SGLT-2i) improve cardiorenal outcomes in chronic kidney disease (CKD) patients with and without type 2 diabetes. The molecular mechanisms underlying these pleiotropic effects remain unclear,...
Conclusion: "A distinct RAS modulation by SGLT-2i occurs in diabetic kidney disease reflected by enhancement of the beneficial Angiotensin-(1–7) providing a molecular background for this renoprotective therapeutic approach."