Effects of a six-month low-carbohydrate diet on glycemic control, body composition and cardiovascular risk factors in patients with type 2 diabetes: an open-label RCT - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34984805/
A non-calorie-restricted LCD high in fat has significant beneficial effects on glycemic control and body composition, and does not adversely affect cardiovascular risk factors in patients with T2D. Reducing carbohydrate...
Conclusion: A non-calorie-restricted LCD high in fat has significant beneficial effects on glycemic control and body composition, and does not adversely affect cardiovascular risk factors in patients with T2D. Reducing carbohydrate intake to 10-25 E% seems an effective and safe nutritional approach with respect to classical cardiovascular risk...
PIEZO1 mediates a mechanothrombotic pathway in diabetes
Source : https://www.science.org/doi/10.1126/scitranslmed.abk1707
Patients with diabetes are at increased risk of thrombosis. Zhu et al. show that the mechanosensitive ion channel PIEZO1 is dysregulated in hematopoietic lineage cells during hyperglycemia. The increased PIEZO1...
Our findings identify a candidate target to precisely modulate mechanically induced thrombosis in T2DM and a potential screening method to predict patient-specific risk. Ongoing remodeling of cell lineages in hematopoiesis is an integral component of thrombotic risk in T2DM, and related mechanisms may have a broader role in chronic disease.
A healthy dietary pattern with a low inflammatory potential reduces the risk of gestational diabetes mellitus - European Journal of Nutrition
Source : https://link.springer.com/article/10.1007/s00394-021-02749-z
Purpose An optimal diet for lowering the risk of gestational diabetes mellitus (GDM) is still to be defined, but may comprise of nutrient intakes, dietary patterns, diet quality, and eating...
Conclusions: "The results emphasize the importance of an overall healthy diet and limitation of foods with SFAs, and other nutrients with a high inflammatory potential in reducing the risk of GDM.
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Facile Photolithographic Fabrication of Zwitterionic Polymer Microneedles with Protein Aggregation Inhibition for Transdermal Drug Delivery
Source : https://pubs.acs.org/doi/10.1021/acs.biomac.1c01325
Microneedle technology has received considerable attention in transdermal drug delivery system research owing to its minimally invasive and convenient self-administration with enhanced transdermal transport. The pre-drug loading microneedle method has...
The microneedles exhibit a high drug loading capacity along with an efficient drug release rate. The rhodamine B drug loading and release model shows that the microneedles can load 8 μg of drugs on one microneedle patch of 41 needles and release nearly 80% of its load within 1 h. We anticipate that this pre-drug loading platform and the...
Early insulin-resistance, T2D and treatment options in childhood - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34915489/
Background T2D (Type 2 Diabetes) represents just the tip of the iceberg of the complex metabolic alterations associated with obesity and other clinical conditions associated to impaired adipose tissue storage....
"This review will focus on the main components defining the risk of IR and T2D in childhood with a specific focus on the main aspects of treatment options available in children and adolescents. Key messages Impaired adipose tissue storage documented in obesity results in a continuous spectrum of metabolic alterations ranging from IR to T2DM....