Share your experience on determining patients' A1C goals
There are multiple factors that weigh in to A1C goals based on patients age, co-morbidities, duration of diabetes, etc.
When deciding to add another medication or switch, what A1C target do you aim for and how does that vary, if at all, depending on various patient characteristics such as:
- diabetes duration
- comorbidities
- age
- risk of hypoglycemia
- patient preference
- other factors?
What percentage of your patients have an A1C goal of 7% or lower?
Generally, my goal would be <7, however, for patients who are elderly, are brittle diabetics, have a short term life expectancy, or struggle with hypoglycemia my goals tend to be high at trying to keep it <8.
More intensive therapy is not always associated with better outcomes.
The ACCORD trial looked at effect of intensive treatment of hyperglycemia on microvascular outcomes in type 2 diabetes in 77 clinical sites in the US. The trial included those w/DMII, A1c >7.5, and either cardiovascular disease vs. >/= 2 CVD risk factors. Participants were randomized to either intensive glycemic control (A1c <6) vs. standard (7-7.9). The intensive therapy arm had to be stopped before trial ended due to higher mortality. Intensive therapy did not reduce the risk of advanced measures of microvascular outcomes, but delayed the onset of albuminuria and some measures of eye complications and neuropathy.
There was also a large retrospective study performed in the UK looking at pts age >50 with DMII. The review assessed survival as a function of A1c. They found that the all cause mortality and cardiac events was higher in those with in the strict A1c decile (A1c 6.4) and those with high A1c (A1c 10.5) decile and the lowest hazard ratio at A1c 7.5.
Therefore, I take an individualized approach in discussing what target A1c goals are with each patient and when they are not at target what underlying factors may be contributing to it.
- In someone who can easily achieve an A1c <7% with meds that don't cause lows, the lower A1c the better, our goal might be low 6s even.
- In someone on intensive insulin therapy who can keep blood sugars tight without having many lows (generally patients with type 2 or some patients with type 1 who just aren't very labile, may have some residual beta cell function) we can aim % but I would note that there is no data supporting A1c < 6.5% for DM1, probably due to the risk of lows.
- In your more typical patient on intensive insulin therapy, A1c goal is probably less important than time in range, average BG by CGM, and % low. These are more the parameters I focus on in the majority of my patients aiming for TIR > 70%, time in low < 3% (varies depending on the patient), and average BG by CGM ~150-160.