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3yr
Program highlights at the 2022 AACAP Annual Meeting

The American Academy of Child and Adolescent Psychiatry/Canadian Academy of Child and Adolescent Psychiatry Annual Meeting kicked off on Oct. 17 in Toronto. Access information on the sessions and speakers covered by our team of analysts.

 

 

 

 

 

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3yr
Program highlights at the 2022 AACAP Annual Meeting

The American Academy of Child and Adolescent Psychiatry/Canadian Academy of Child and Adolescent Psychiatry Annual Meeting kicked off on Oct. 17 in Toronto. Access information on the sessions and speakers covered by our team of analysts.

 

  • Saved

3yr
The developmental consequences of early adverse care on infant macaques: A cross-fostering study

The developmental consequences of early adverse care on infant macaques: A cross-fostering study

Source : https://www.sciencedirect.com/science/article/abs/pii/S0306453022002888?via=ihub

Early life adversity/stress (ELA/ELS), particularly adverse caregiving experiences such as child maltreatment (MALT), is a main risk factor for psychopathology, including psychiatric disorders such as anxiety, depression, ADHD, and substance...


Conclusions:Monkeys who were maternally maltreated demonstrate heightened emotional reactivity. Monkeys who were maternally maltreated exhibit higher levels of chronic stress. Maltreating mothers provide an overall lower quality of care to their infants.

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3yr
Associations of DNA Methylation With Behavioral Problems, Gray Matter Volumes, and Negative Life Events Across Adolescence: Evidence From the Longitudinal IMAGEN Study

Associations of DNA Methylation With Behavioral Problems, Gray Matter Volumes, and Negative Life Events Across Adolescence: Evidence From the Longitudinal IMAGEN Study

Source : https://www.biologicalpsychiatryjournal.com/article/S0006-3223(22)01356-7/fulltext

Negative life events (NLEs) increase the risk for externalizing behaviors (EBs) and internalizing behaviors (IBs) in adolescence and adult psychopathology. DNA methylation associated with behavioral problems may reflect this risk...


Conclusions: Our findings suggest that novel epigenetic mechanisms through which NLEs exert short and longer-term effects on behavior may contribute to ADHD.


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3yr
Quantitative Characterization of the Smoothness of Extended-release Methylphenidate Pharmacokinetic Profiles

Quantitative Characterization of the Smoothness of Extended-release Methylphenidate Pharmacokinetic Profiles

Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9507140/

Innov Clin Neurosci. 2022 Jul-Sep; 19(7-9): 32-37. Extended-release methylphenidate (ER-MPH) formulations used to treat attention deficit hyperactivity disorder (ADHD) have complex pharmacokinetic (PK) profiles, resulting from differing ratios of immediate-release...


Conclusions: DR/ER-MPH demonstrated a smoother PK profile compared to the highest dose of other ER-MPH formulations. While the benefits of a smooth PK profile remain to be tested clinically, having fewer peaks and troughs has been hypothesized to reduce waxing and waning of therapeutic effects throughout the day, and more gradual changes in MPH...