Transmitted drug resistance to integrase based first-line HIV antiretroviral regimens in the Mediterranean Europe - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36571282/
We present the most recent data on TDR to integrase based first-line regimens in Europe. Given the low prevalence of CRR to second generation integrase inhibitors and to first-line NRTIs,...
Conclusions: We present the most recent data on TDR to integrase based first-line regimens in Europe. Given the low prevalence of CRR to second generation integrase inhibitors and to first-line NRTIs, in the years 2018-2021 it is unlikely that newly diagnosed PWH in MeditRes countries would present with baseline resistance to a first-line...
A case report of clinical implications of a delayed antiretroviral therapy switch in a patient with multiple treatment interruptions - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36569036/
The Namibia national antiretroviral therapy guidelines recommend that patients living with HIV who interrupt antiretrovirals and in the process disengage from care be restarted on their usual antiretroviral therapy regimen...
Conclusions: The Namibia national ART guidelines are aligned with the WHO recommendations for a standardized treatment. Nevertheless, regarding patients returning to care after ART interruption, previous ARVs exposure and VL results are essential in guiding the management. To avoid treatment switch delays in patients failing ART, we recommend...
LL-37 antimicrobial peptide and heterologous prime-boost vaccination regimen significantly induce HIV-1 Nef-Vpr antigen- and virion-specific immune responses in mice - Biotechnology Letters
Source : https://link.springer.com/article/10.1007/s10529-022-03339-7
Objectives HIV infection still remains a leading cause of morbidity and mortality worldwide. The inability of highly-active antiretroviral therapy in HIV-1 eradication led to development of therapeutic vaccines. Exploiting effective...
Conclusions: Generally, the use of LL-37 for DNA delivery, Montanide 720 as an adjuvant, and heterologous DNA prime/protein boost strategy could significantly increase IgG2a, IFN-gamma, and Granzyme B, and maintain cytokine secretion after exposure to virions. Indeed, the heterologous DNA LL-37 prime/protein Montanide boost regimen...
Development and validation of a liquid chromatography coupled to tandem mass spectrometry method for the monitoring of temsavir plasma concentrations in people living with HIV
Source : https://www.sciencedirect.com/science/article/pii/S1570023222004809?via=ihub
A fast LC-MS/MS method was developed for the quantification of temsavir in plasma. * The method was validated over a large range of concentrations. * The method will be used...
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Conclusions: Fostemsavir (RUKOBIA®) is the prodrug of temsavir, a first-in-class oral attachment inhibitor approved for the treatment of heavily treatment-experienced adults with multidrug-resistant HIV-1 infection. In this case RUKOBIA® is part of a complex regimen of antiretroviral drugs, often in addition to other drugs for chronic...
Conclusions and Relevance: In this cluster randomized trial, the multisectoral agricultural intervention led to demonstrable health and other benefits; however, it was not possible to detect additional effects of the intervention on HIV clinical indicators. Agricultural interventions that improve productivity and livelihoods hold promise as a...