Long-Acting Formulations for the Prevention and Treatment of Human Immunodeficiency Virus (HIV)-1 Infection: Strategic Leveraging and Integration of Multidisciplinary Knowledge to Advance Public Health - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36410378/
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Relevance: We discuss some unique LA-ARV drug development considerations, including the use of an oral lead-in, and assessing the impact of residual ARV exposures on subsequent regimens and evaluation of LA-ARVs in specific populations. We strongly believe that efficient integration of multidisciplinary knowledge can advance the development,...
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Conclusions/Relevance: Findings provide a unique aspect of the interrelations of COVID and living with HIV. Since health behaviors and outcomes for COVID-19 and HIV seem to be interrelated, treatment practices and interventions that address these simultaneously may enhance their efficacy.
Potential drug-drug interactions due to concomitant medicine use among people living with HIV (PLWH) on antiretroviral therapy in Australia - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36434744/
doi: 10.1111/bcp.15614. Online ahead of print. 1 Medicines Intelligence Research Program, School of Population Health - Faculty of Medicine and Health/UNSW Sydney. 2 Centre for Big Data Research in Health...
Conclusions: Concomitant medicine use is widespread amongst PLWH in Australia. Despite a relatively low prevalence of contraindicated medicines, almost a third received medicines that require close monitoring or dose adjustment.
A national household survey on HIV prevalence and clinical cascade among children aged ≤15 years in Kenya (2018)
Source : https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0277613
We analyzed data from the 2018 Kenya Population-Based HIV Impact Assessment (KENPHIA), a cross-sectional, nationally representative survey, to estimate the burden and prevalence of pediatric HIV infection, identify associated factors,...
Conclusions/Relevance: The KENPHIA survey confirms a substantial HIV burden among children in Kenya, especially among orphans.
Realizing the promise of long-acting antiretroviral treatment strategies for individuals with HIV and adherence challenges: an illustrative case series - AIDS Research and Therapy
Source : https://aidsrestherapy.biomedcentral.com/articles/10.1186/s12981-022-00477-w
Background Adherence to antiretroviral treatment (ART) remains the cornerstone of optimal HIV outcomes, including viral suppression (VS), immune recovery, and decreased transmission risk. For many people with HIV (PWH), particularly...
Relevance: This paper reports on three young PWH with poor adherence to oral ART and initial viremia being successfully managed with LAI-ART. Although many clinical trials have reported findings on the efficacy, tolerability, or acceptability of LAI-ART, this is one of the first case series that reports on the outcomes of LAI-ART use among...