Regular Testing of HIV and Sexually Transmitted Infections With Self-Collected Samples From Multiple Anatomic Sites to Monitor Sexual Health in Men Who Have Sex With Men: Longitudinal Study
Source : https://formative.jmir.org/2022/11/e40996
Background: Regular HIV and sexually transmitted infection (STI) testing for men who have sex with men (MSM) is an important means of infection prevention, the adoption of which remains suboptimal...
Conclusions: Both baseline prevalence and incidence of STI were high among MSM engaged in regular testing. A high degree of engagement in regular STI and HIV testing was positively associated with incident STI, history of health-seeking behaviors, and perceived convenience of self-sampling. Self-sampling could be introduced as a means of...
Comparison of the design and methodology of Phase 3 clinical trials of bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) and dolutegravir-based dual therapy (DTG) in HIV: a systematic review of the literature - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36399521/
doi: 10.1080/14787210.2023.2149490. Online ahead of print. 1 Pharmacy Department, Hospital del Mar, Barcelona, Spain. 2 Department of Infectious Diseases, Hospital Clinic-IDIBAPS, University of Barcelona, Barcelona, Spain. 3 CIBERINFEC, Instituto de...
Expert Opinion: The search identified 5, 3 and 2 phase 3 RCTs with BIC/FTC/TAF, DTG/3TC and DTG/RPV, respectively, that met the inclusion criteria. The designs would not be comparable due to differences in pre-randomisation losses, blinding, patient recruitment, as well as differences in methodological quality, with the average score of the...
Dolutegravir-containing HIV therapy reversibly alters... : AIDS
is emerging evidence of off-target effects and toxicities. Although limited in number, recent reports have highlighted the vulnerability of mitochondria to these toxicities. The aim of the present study is...
Conclusions: Taken together, our observations indicate that DTG-containing regimens negatively impact cellular and mitochondrial health and may be more toxic to mitochondria, even among the generally well-tolerated InSTI-based cART.
Meaning in life, goals, and adherence to antiretroviral treatment in people living with HIV - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36367188/
Patients living with HIV who do not adhere to antiretroviral treatment (ART) have a high viral load, increasing the risk of developing AIDS, as well as new treatment-resistant strains. There...
Conclusion: We conclude that the design of programs to improve ART adherence should promote the establishment of personal development goals and offer tools that allow having a sense of meaning in life to reduce AIDS-related complications.
The Health Gym: synthetic health-related datasets for the development of reinforcement learning algorithms - Scientific Data
Source : https://www.nature.com/articles/s41597-022-01784-7
In recent years, the machine learning research community has benefited tremendously from the availability of openly accessible benchmark datasets. Clinical data are usually not openly available due to their confidential...
Relevance: In recent years, the machine learning research community has benefited tremendously from the availability of openly accessible benchmark datasets. Clinical data are usually not openly available due to their confidential nature. This has hampered the development of reproducible and generalisable machine learning applications in health...