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Conclusions: These data show that routine pharmacy data can act as a highly predictive mechanism for identifying patients at risk of VNS and VF due to nonadherence.
HIV-1 genetic diversity and transmitted drug resistance to integrase strand transfer inhibitors among recently diagnosed adults in Porto Alegre, South Brazil - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36272141/
All 42 ARV-naive individuals were apparently susceptible to INSTIs, included in the Brazilian therapeutic guideline since 2009. To the best of our knowledge, this is the first study to evaluate...
Conclusions: All 42 ARV-naive individuals were apparently susceptible to INSTIs, included in the Brazilian therapeutic guideline since 2009. To the best of our knowledge, this is the first study to evaluate TDRMs against INSTIs in Brazil. The most prevalent HIV-1 subtypes were subtype C, followed by the recombinant BC and subtype B, which is in...
Medicaid Spending on Antiretrovirals from 2007-2019
From 2007-2019, Medicaid spending on antiretroviral medications to treat HIV increased by 178%, driven by increased use and higher prices for newer treatments.
Conclusions: Annual Medicaid net spending on ARVs nearly tripled from 2007 to 2019, due to a combination of expanded use and rising prices. Medicaid did not extract expected benefits from its mandatory inflationary rebates because they were offset by use of newer, more expensive ARVs. To better control spending related to products with...
Lower insulin sensitivity in newborns with in utero HIV and antiretroviral exposure who are uninfected in Botswana - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36240387/
doi: 10.1093/infdis/jiac416. Online ahead of print. 1 ¹Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Department of Pediatrics, Division of Pediatric Infectious Diseases. 2 Ann and Robert H. Lurie...
Conclusions: Newborns HEU vs. HUU had lower insulin sensitivity at birth and at 1 month of life, raising potential concern for obesity and other metabolic perturbations later in life for newborns HEU.
Development and Evaluation of Dissolving Microarray Patches for Co-administered and Repeated Intradermal Delivery of Long-acting Rilpivirine and Cabotegravir Nanosuspensions for Paediatric HIV Antiretroviral Therapy - Pharmaceutical Research
Source : https://link.springer.com/article/10.1007/s11095-022-03408-6
Purpose Whilst significant progress has been made to defeat HIV infection, the efficacy of antiretroviral (ARV) therapy in the paediatric population is often hindered by poor adherence. Currently, two long-acting...
Conclusions:These results illustrate the potential of the platform to repeatedly maintain plasma concentrations for RPV and CAB. As such, these MAPs could represent a viable option to improve adherence in the paediatric population, one that is capable of being painlessly administered in the comfort of the patient’s own home on a biweekly or...