Long-acting HIV Pre-exposure Prophylaxis (PrEP) approaches: Recent advances, emerging technologies and development challenges
Source : https://www.tandfonline.com/doi/full/10.1080/17425247.2022.2135699
Abstract Abstract Poor or inconsistent adherence to daily oral pre-exposure prophylaxis (PrEP) has emerged as a key barrier to effective HIV prevention. The advent of potent long-acting (LA) antiretrovirals (ARVs)...
Expert Opinion The HIV prevention field is evolving faster than ever and the bar for developing next-generation LA HIV prevention options continues to rise. The requirements for viable LA PrEP products to be implemented in resource-limited settings is challenging, necessitating proactive consideration and product modifications during the design...
HIV-1 infection enhances innate function and TLR7 expression in female plasmacytoid dendritic cells
Source : https://www.life-science-alliance.org/content/5/10/e202201452
Plasmacytoid dendritic cells (pDCs) express TLR7, a ssRNA-sensor encoded on the X chromosome, which escapes X chromosome inactivation (XCI) in females. pDCs are specialized in the production of type 1...
Conclusions: These data reinforce the interest in targeting the HIV-1 reservoir using TLR7 agonists in women.
'If I am playing football, I forget that I have this virus': the challenges and coping strategies of adolescents with perinatally acquired HIV in KwaZulu-Natal, South Africa - BMC Infectious Diseases
Source : https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-022-07780-x
Background Adolescents who have acquired HIV perinatally (ALHIV) face unique challenges in taking lifelong antiretroviral therapy (ART), but little is known about what factors affect their adherence over the course...
Conclusions: Current models of adherence support fail to address the challenges to lifelong therapy ALHIV face. Ongoing education and honest communication with health care providers, interventions that build resilience together with peer support, have the potential to improve adherence in ALHIV."
Evaluation of HIV viral load turnaround time in Moshi, Tanzania
Source : https://www.jidc.org/index.php/journal/article/view/14145
Elizabeth L Moirana Kilimanjaro Christian Medical Centre (KCMC), Moshi, Tanzania Eva Prosper Muro Kilimanjaro Christian Medical Centre (KCMC), Moshi, Tanzania Ireen Eliah Kiwelu Kilimanjaro Christian Medical Centre (KCMC), Moshi, Tanzania...
Conclusions: The median viral load turnaround time was longer than stipulated by the national Tanzanian guidelines. Interventions that may reduce viral load turn-around-time, including point of care viral load testing, are needed to optimise monitoring of anti-retroviral therapy.
Comparing dedicated and designated approaches to integrating task-shared psychological interventions into chronic disease care in South Africa: a three-arm, cluster randomised, multicentre, open-label trial
Source : https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)01641-5/fulltext
The dedicated and designated approaches to delivering CHW-led psychological interventions were equally effective for reducing depression, but enhancements are required to support alcohol reduction. This trial extends evidence for CHW-delivered...
Interpretation:The dedicated and designated approaches to delivering CHW-led psychological interventions were equally effective for reducing depression, but enhancements are required to support alcohol reduction. This trial extends evidence for CHW-delivered psychological interventions, offering insights into how different delivery approaches...