Transfer of antiretroviral drugs into breastmilk: a prospective study from the Swiss Mother and Child HIV Cohort Study
Source : https://academic.oup.com/jac/advance-article/doi/10.1093/jac/dkac337/6731709?login=false
Until recently, guidelines in high-income settings advised women living with HIV not to breastfeed and to give formula milk to their babies. Due to the important health advantages of breastfeeding...
Conclusions: ARVs were transferred to a variable extent in breastmilk. Nevertheless, the estimated daily ARV dose from breastfeeding remained low. Differential ARV exposure was observed in breastfed infants with some ARVs being below/above their effective concentrations raising the concern of resistance development if HIV infection occurs. More...
Progress towards the UNAIDS 90-90-90 targets among persons aged 50 and older living with HIV in 13 African countries - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36176030/
While OPLWH in these 13 countries were slightly more likely than younger people to be aware of their HIV-positive status (first 90), this target was not achieved in most countries....
Conclusions: While OPLWH in these 13 countries were slightly more likely than younger people to be aware of their HIV-positive status (first 90), this target was not achieved in most countries. However, OPLWH achieved treatment (second 90) and VL suppression (third 90) targets in more countries than PLWH
Impact of antiretroviral therapy in primary HIV infection on natural killer cell function and the association with viral rebound and HIV DNA following treatment interruption
Source : https://www.frontiersin.org/articles/10.3389/fimmu.2022.878743/full
Natural Killer (NK) cells play a key role in controlling HIV replication, with potential downstream impact on the size of the HIV reservoir and likelihood of viral rebound after antiretroviral...
Conclusions: These data show NK cell functions are heterogeneously impacted by HIV infection with a mixed picture of resolution on ART, and that while NK cells may affect HIV DNA levels and time to viral rebound, no single NK cell marker defined delayed viral rebound.
Health insurance coverage, clinical outcomes, and health-related quality of life among youth born to women living with HIV - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36150048/
doi: 10.1097/QAI.0000000000003100. Online ahead of print. 1 Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA. 2 Center for Global Health and Mongan Institute, Massachusetts General Hospital,...
Conclusion: These findings suggest meaningful differences in ART adherence and some HR-QoL outcomes by health insurance coverage among young adults born to WLHIV.
Previous Syphilis Not Associated with Neurocognitive Outcomes in People Living with HIV in Ontario, Canada - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36150077/
In this sample, prior syphilis was not associated with worse neurocognitive outcomes over time according to self-reported scales or objective neuropsychological testing.
Conclusions: In this sample, prior syphilis was not associated with worse neurocognitive outcomes over time according to self-reported scales or objective neuropsychological testing.