Inflammation and Intracellular Exposure of Dolutegravir, Darunavir, Tenofovir and Emtricitabine in People living with HIV - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36115063/
doi: 10.1111/bcp.15538. Online ahead of print. 1 Unit of Infectious Diseases, Department of Medical Sciences, University of Turin, Turin, Italy. 2 Laboratory of Clinical Pharmacology and Pharmacogenetics, Department of Medical...
Conclusions: Our preliminary data support the hypothesis of lower DRV and DTG IC concentrations and lower TFV plasma exposure in patients with higher plasma IM suggesting an interplay between HIV drug penetration and persistent inflammation in cART-treated HIV-positive patients.
Magnitude and predictors of first-line antiretroviral therapy regimen change among HIV infected adults: A retrospective cross sectional study
Source : https://www.sciencedirect.com/science/article/pii/S2049080122010639?via=ihub
The majorities (57.4%) of the patients were female and the mean age of the study participants was 32.9 ± 9.5 * A total of 165 (21.4%) participants experienced antiretroviral regimen...
Conclusions: The rate of initial HAART regimen change was found to be high. Thus, less toxic and better tolerated HIV treatment options should be available and used more frequently. Moreover, early detection and initiation of ART by the government is highly demanded to maximize the benefit and reduce risk of ART modifications.
Sex-Differences in Subclinical Atherosclerosis and Systemic Immune Activation/Inflammation among People with HIV in the U.S.
Source : https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciac767/6697021?login=false
AbstractBackground. August Among people with HIV (PWH), sex-differences in presentations of atherosclerotic cardiovascular disease (ASCVD) may be influenced by
Conclusions: Among U.S. PWH, females had a lower prevalence of plaque and NC/V-P, as well as differences in key immune/inflammatory biomarkers. Immune-plaque relationships differed by sex for D-dimer, but not other tested parameters.
Improved virologic outcomes in postpartum women living with HIV referred to differentiated models of care: a randomised controlled trial - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36111547/
doi: 10.1097/QAD.0000000000003385. Online ahead of print. 1 Division of Epidemiology & Biostatistics, School of Public Health & Family Medicine, University of Cape Town. 2 Provincial Government of the Western Cape....
Conclusions: Early DSD referral was associated with reduced viraemia through 24 months postpartum and may be an important strategy to improve maternal virologic outcomes.
Multimorbidity of communicable and non-communicable diseases in low- and middle-income countries: A systematic review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36081708/
The identification and prevention of risk factors and addressing evidence gaps in multimorbidity clustering is crucial to address the increasing communicable and non-communicable disease multimorbidity in LMICs. To identify communicable...
Conclusion: The identification and prevention of risk factors and addressing evidence gaps in multimorbidity clustering is crucial to address the increasing communicable and non-communicable disease multimorbidity in LMICs. To identify communicable and non-communicable diseases trends over time and identify causal relationships, longitudinal...