Comparative Efficacy and Safety of Fostemsavir in Heavily Treatment-Experienced People With HIV-1
Source : https://www.clinicaltherapeutics.com/article/S0149-2918(22)00146-1/fulltext
Heavily treatment-experienced (HTE) people with multidrug-resistant HIV-1 have limited treatment options. Treatment with the first-in-class attachment inhibitor fostemsavir in addition to optimized background therapy (OBT) resulted in sustained virologic and...
Conclusions: Implications: Although matching-adjusted indirect comparison analyses have limitations, these results support the use of fostemsavir and OBT as an important treatment option in HTE people with multidrug-resistant HIV-1.
Virological failure and treatment switch after ART initiation among people living with HIV with and without routine viral load monitoring in Asia - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36028921/
PLHIV from non-routine VL sites had a higher incidence of persistent VF and a low switching regimen rate, reflecting possible under-utilized VL testing.
Conclusions: PLHIV from non-routine VL sites had a higher incidence of persistent VF and a low switching regimen rate, reflecting possible under-utilized VL testing.
Determinants of Survival of HIV Patients Receiving Dolutegravir: A Prospective Cohort Study in Conflict-Affected Bunia, Democratic Republic of Congo - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36011850/
This study aims to determine the factors influencing HIV-related mortality in settings experiencing continuous armed conflict atrocities. In such settings, people living with HIV (PLHIV), and the partners of those...
Conclusions: Improving baseline viral load monitoring, starting ART early in individuals with high baseline viral loads, the proper tailoring of ART regimens and optimizing long-term ART, and care to manage non-AIDS-related chronic complications are recommended actions to reduce mortality. Not least, fostering women's inclusion, justice, peace,...
HIV-1 RNA levels in rectal and seminal compartments after switching to long-acting cabotegravir plus rilpivirine: a longitudinal study
You do not currently have access to this article. Don't already have an Oxford Academic account? Register HIV-1 RNA levels in rectal and seminal compartments after switching to long-acting cabotegravir...
/>
Conclusions:. Maintenance of viral suppression in rectal and seminal compartments was comparable and blips occurred with similar frequency with both treatment regimens.
Effect of Rifabutin in Dolutegravir Dosing: A Case Series - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36026587/
Background: Tuberculosis (TB) is the leading cause of death in human immunodeficiency virus (HIV)-infected people worldwide. Currently there are no studies examining the use of Rifabutin (RBN) and Dolutegravir (DTG)...
Conclusions: Given the frequency of low DTG and RBN concentrations, therapeutic drug monitoring (TDM) for these drugs is advisable. Prospective clinical studies are needed to further determine the PK interactions between RBN and DTG, and virologic response to treatment.