In-vivo pharmacokinetic studies of Dolutegravir loaded spray dried Chitosan nanoparticles as milk admixture for paediatrics infected with HIV - Scientific Reports
Source : https://www.nature.com/articles/s41598-022-18009-x
Dolutegravir (DTG) is an antiretroviral drug approved in the year 2013, and being categorized as a BCS-II molecule, it possesses solubility issues. In order to enhance the solubility and improve...
Conclusion: Altogether, the research findings showed that Chitosan-based NPs were ideal carriers for oral administration of DTG along with milk and exhibited great potential to enhance the bioavailability of the drug and treatment adherence for paediatric HIV patients.
A Phase IV Study on Safety, Tolerability and Efficacy of Dolutegravir, | POR
Human Immunodeficiency Virus Type 1 (HIV-1) remains a global health problem with an estimated 37.6 million people globally living with HIV-1 in 2020. Most of these cases were reported from...
Conclusion: This study demonstrated the safety and efficacy of DTG based regimen in treatment naïve HIV-1 patients in Indian population and support use of DTG as first-line treatment regimen.
Effects of the androgen receptor inhibitor enzalutamide on the pharmacokinetics of dolutegravir and tenofovir: a case report - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35979833/
Enzalutamide is an androgen receptor inhibitor used for the treatment of prostate cancer. Although enzalutamide causes a favorable adverse effect profile, it might cause drug-drug interactions with some antiretrovirals. No...
Relevance: Enzalutamide is an androgen receptor inhibitor used for the treatment of prostate cancer. Although enzalutamide causes a favorable adverse effect profile, it might cause drug–drug interactions with some antiretrovirals.
Virologic impact of the dolutegravir transition: prospective results from the multinational African Cohort Study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35980350/
doi: 10.1097/QAI.0000000000003065. Online ahead of print. 1 U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA. 2 Henry M. Jackson Foundation for the Advancement...
Conclusion: PLWH transitioning to TLD had higher rates of viral suppression compared to those who remained on other regimens. Even within a highly suppressed population, TLD transition provided significant benefit for achieving or maintaining viral suppression.
Adaption of an ongoing clinical trial to quickly respond to gaps in changing international recommendations: the experience of D 2 EFT - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35938597/
A rapidly changing landscape of antiretrovirals and their procurement at scale has permitted the evaluation of new optimised second-line antiretroviral therapy (ART) in low- and middle-income countries. D 2 EFT...
Conclusion/Relevance: The D2EFT study maintains additional value in a quickly evolving second-line ART strategy allowed by the progress in global access to ART