Efficacy, durability, and tolerability of dolutegravir/lamivudine and dolutegravir/rilpivirine for the treatment of HIV in a real-world setting in Belgium - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35938381/
doi: 10.1111/hiv.13373. Online ahead of print. 1 Saint-Pierre University Hospital, Brussels, Belgium. 2 Cliniques Universitaires Saint-Luc, Brussels, Belgium. 3 Liège University Hospital, Liège, Belgium. 4 Institute of Tropical Medicine, Antwerp,...
Conclusion: In this real-world analysis, the 2DRs analysed were effective, durable, and safe for both treatment-naïve and treatment-experienced patients. A slight increase in weight was associated with these regimens.
Virological efficacy of switch to DTG plus 3TC in a retrospective observational cohort of suppressed HIV-1 patients with or without past M184V - The LAMRES Study
Source : https://www.sciencedirect.com/science/article/pii/S2213716522001898?via=ihub
In real-life settings, virological rebound after DTG+3TC switch is very low. * M184V in a context of short virological suppression might affect DTG+3TC response. * Further ad hoc clinical trials...
Conclusion/Relevance: A high rate (95%) of VS was observed among children and adolescents on TLD in rural Zimbabwe. TLD may address the problems of virologic failure and emergence of resistance in Africa. However, longer follow up might be needed to ascertain sustained VS in this vulnerable population.
Parental Efficacy in Managing Smartphone Use of Adolescents with Attention-Deficit/Hyperactivity Disorder: Parental and Adolescent Related Factors
Source : https://www.liebertpub.com/doi/10.1089/AID.2021.0140
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Conclusion/Relevance: This study demonstrated that both parental and adolescent factors contribute to PEMASU among parents of adolescents with ADHD. Intervention programs aiming to enhancing PEMASU need to take these related factors into consideration.
Tracking adverse drug reactions and medication errors in the Central Chronic Medicine Dispensing and Distribution (CCMDD) programme in South Africa
Source : https://sajhivmed.org.za/index.php/HIVMED/article/view/1366
The Southern African Journal of HIV Medicine is focused on HIV/AIDS treatment, prevention and related topics relevant to clinical and public health practice. The purpose of the journal is to...
Conclusion: About one in seven patients reported ADRs under TLD. Medication errors were low, possibly due to effective quality control measures and stable patients being on the programme. Knowing the frequency of ADRs and medication errors is critical for enhancing the CCMDD programme.
Excessive weight gain: current antiretroviral agents in virologically suppressed people with HIV
Source : https://www.liebertpub.com/doi/10.1089/AID.2021.0188
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Conclusion: In this study of virologically suppressed, ART-experienced PWH switching to regimens containing TAF/FTC and either DRV/c, EVG/c, DTG or BIC, up to 18% experienced excessive levels of weight gain. However, no statistically significant difference was observed across regimens.