Factors Associated with Use of HIV Prevention and Health Care Among Transgender Women - Seven Urban Areas, 2019-2020 - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35588092/
Transgender women* are disproportionately affected by HIV. Among 1,608 transgender women who participated in CDC's National HIV Behavioral Surveillance (NHBS) during 2019-2020, 42% received a positive HIV test result (1)....
Conclusion: These findings illustrate the benefit of gender-affirming approaches used by health care providers, and highlight the challenging socioeconomic conditions faced by many transgender women. Ensuring access to gender-affirming health care approaches and addressing the socioeconomic challenges of many transgender women could improve...
Active Pharmacovigilance Project on the safety profile of Dolutegravir in Brazil
Source : https://www.tandfonline.com/doi/abs/10.1080/09540121.2022.2062289?journalCode=caic20
ABSTRACT A quantitative descriptive study based on Brazilian Active Pharmacovigilance of Dolutegravir (DTG) Project was performed to describe the adverse drug reactions (ADRs) to DTG reported and to evaluate the...
Conclusion: The frequency of ADR was low in relation to the number of people living with HIV (PLHIV) using DTG in Brazil, which suggests good tolerability and safety of DTG. The DTG active pharmacovigilance database in Brazil showed good data completeness.
HIV virological non-suppression is highly prevalent among 18- to 24-year-old youths on antiretroviral therapy at the Kenyan coast - BMC Infectious Diseases
Source : https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-022-07428-w
Background In sub-Saharan Africa, data on virologic outcomes of young people living with HIV (YLWH) enrolled on antiretroviral therapy (ART) remains scarce. In this study, we describe the prevalence of...
Conclusions: In this study, high levels of VNS were observed among YLWH and this was significantly associated with rural residency, nutritional and ART adherence problems. ART adherence counselling and nutritional support and education should be intensified in this setting targeting YLWH residing mostly in rural areas. Given the high frequency...
Pharmacogenetics of dolutegravir plasma exposure among Southern Africans living with HIV
Source : https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiac174/6580078?login=false
AbstractBackground. Dolutegravir is a component of preferred antiretroviral therapy (ART) regimens. We characterised the pharmacogenetics of dolutegravir exposu
Conclusions: In South Africa, rs887829 and rs28899168 in the UGT1A locus were independently associated with dolutegravir AUCVAR. The novel rs28899168 association warrants replication. This study enhances understanding of dolutegravir pharmacogenetics in Africa.
Comparison of the Efficacy and Safety of a Doravirine-Based, Three-Drug Regimen in Treatment-Naïve HIV-1 Positive Adults: A Bayesian Network Meta-Analysis
Source : https://www.frontiersin.org/articles/10.3389/fphar.2022.676831/full
Introduction: Extensive use of antiretroviral therapy has remarkably improved the survival rates of people living with HIV. Doravirine (DOR) is a newly-approved antiretroviral belonging to the class of non-nucleoside reverse...
Conclusion: The network meta-analysis showed that DOR TDF 3TC/FTC has good efficacy and safety at 48 weeks.