Cost-effectiveness of easy-access, risk-informed oral pre-exposure prophylaxis in HIV epidemics in sub-Saharan Africa: a modelling study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35489378/
1 Institute for Global Health, University College London, London, UK. Electronic address: [email protected]. 2 Department of Population Health, New York University Grossman School of Medicine, New York, NY, USA. 3...
Interpretation: Under the assumption that making PrEP easily accessible for all adults in sub-Saharan Africa in the context of community education leads to risk-informed use, PrEP is likely to be cost-effective in settings with prevalence of HIV viral load greater than 1000 copies per mL among all adults higher than 2%, suggesting the need for...
Pharmacokinetics, safety, tolerability, and antiviral activity of dolutegravir dispersible tablets in infants and children with HIV-1 (IMPAACT P1093): results of an open-label, phase 1-2 trial - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35489377/
Collaborators, Affiliations 1 University of California, San Francisco, San Francisco, CA, USA. Electronic address: [email protected]. 2 University of Alabama at Birmingham, Birmingham, AL, USA. 3 Frontier Science & Technology and...
Interpretation: In this study, the proposed once daily dosing of dolutegravir dispersible tablets provided drug exposures similar to those for adults, and was safe and well tolerated. These data support the use of dolutegravir dispersible tablets as first-line or second-line treatment for infants and children aged less than 6 years living...
Oral human papillomavirus prevalence, persistence, and risk-factors in HIV-positive and HIV-negative adults
Source : https://www.sciencedirect.com/science/article/pii/S2666679022000039?via=ihub
HIV has been shown to increase the likelihood of oral HPV infection. In this study, we evaluated the risk of oral HPV in HIV infected patients compared with HIV-negative controls....
Conclusions: Risk of oral HPV infection and persistence was significantly higher in HIV adults with a history of poorly controlled HIV, which may put them at increased risk of HPV-associated cancer.
Exposure of human immune cells, to the antiretrovirals efavirenz and lopinavir, leads to lower glucose uptake and altered bioenergetic cell profiles through interactions with SLC2A1 - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35461087/
SLC2A1 mediates glucose cellular uptake; key to appropriate immune function. Our previous work has shown efavirenz and lopinavir exposure inhibits T cell and macrophage responses, to known agonists, likely via...
Conclusion: Our data suggest a role for efavirenz and lopinavir in the alteration of glucose accumulation with subsequent alteration of bioenergetic profiles, supporting our hypothesis for their inhibitory effect on immune cell activation. Clarification of the implications of this data, for in vivo immunological responses, is now warranted to...
Mean generation function model in AIDS epidemic estimation - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35429984/
doi: 10.1186/s12911-022-01825-6. 1 Department of Health Management, Faculty of Health Service, Second Military Medical University, Naval Medical University, No. 800 Xiangyin Road, Shanghai, 200433, People's Republic of China. 2 Department...
Conclusion: The mean birth function model was an effective method to monitor and predict the changing trend of AIDS incidence and mortality in China.