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Brief Virtual Intervention Associated With Increased Social Engagement and Decreased Negative Affect Among People Aging With HIV

Brief Virtual Intervention Associated With Increased Social Engagement and Decreased Negative Affect Among People Aging With HIV

Source : https://pubmed.ncbi.nlm.nih.gov/38497407/

Virtual Villages-online communities that deliver supports to promote aging in place-are proposed to mitigate isolation and support the health of aging populations. Using a community-engaged approach, we developed and pilot-tested...

Results suggested that a virtual community can be accessible to older people living with HIV infection and may enhance social engagement and improve their aspects of mental wellbeing.

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Nurse-led CV risk factor management in academic HIV clinics may lead to fewer CV events and should inform implementation of prevention programs for people with HIV.

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Pharmacological Approaches to Promote Cell Death of Latent HIV Reservoirs

Pharmacological Approaches to Promote Cell Death of Latent HIV Reservoirs

Source : https://journals.lww.com/co-hivandaids/abstract/2024/03000/pharmacological_approaches_to_promote_cell_death.4.aspx

One approach is to combine latency reversal agents with proapoptotic compounds and cytotoxic T cells to first reactivate and then clear infected cells. Other strategies include using natural killer cells...

Achieving a clinically significant reduction in the size of the reservoir will likely require a combination strategy since none of the approaches pursued so far has been successful on its own in clinical trials.

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Geometric mean abacavir and lamivudine exposures were higher at 6 to 14 days than at 19- to 24 days of age, whereas they were similar for lopinavir over this period.

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Age at ART Initiation and Proviral Reservoir Size in Perinatal HIV-1 Infection: Considerations for ART-Free Remission

Age at ART Initiation and Proviral Reservoir Size in Perinatal HIV-1 Infection: Considerations for ART-Free Remission

Source : https://journals.lww.com/co-hivandaids/fulltext/2024/03000/age_at_art_initiation_and_proviral_reservoir_size.7.aspx

The insights gathered from this review serve to inform the field on the unique dynamics of HIV-1 reservoir size in perinatal HIV-1 infection as a function of age at ART...

Despite similar pre-ART baseline HIV-1 DNA levels, very early treatment results in lower levels of HIV-1 DNA in early childhood.