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Psychometric Evaluation of the MENQOL Instrument in Women Experiencing Vasomotor Symptoms Associated With Menopause

Psychometric Evaluation of the MENQOL Instrument in Women Experiencing Vasomotor Symptoms Associated With Menopause

Source : https://pubmed.ncbi.nlm.nih.gov/38396203/

ClinicalTrials.gov identifiers NCT04003155 and NCT04003142.

Overall, the results provided evidence of acceptable psychometric properties of the Menopause-Specific Quality of Life overall and domain scores using 1-week recall.

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Novel MOA targets age-old condition

Hot flashes—experienced by 70%-80% of menopausal women—are physically distressing and worsen quality of life. Newer therapies, such as NK3R antagonists, leverage a non-hormonal approach to addressing these symptoms.

For example, fezolinetant is a selective NK3R antagonist that directly blocks NKB from binding to the KNDy neuron. NKB is a known trigger of vasomotor symptoms (VMS).

KNDy neurons located at the level of the hypothalamus are inhibited by estrogen and triggered by the neuropeptide NKB, thus resulting in the regulation of body temperature.

During menopause, estrogen decline interferes with this balance involving NKB. Left unopposed, NKB signaling increases KNDy neuronal activity. This process sets off heat-dissipation mechanisms, such as vasodilation and sweating (or VMS).

Thus, fezolinetant helps decrease the frequency and intensity of hot flashes and night sweats, honing in on NK3R with an affinity 450 times higher than that of NK1 or NK2 receptors.

What are your thoughts on this new mechanism of action for the treatment of VMS?

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Bone Health in Women With Premature Ovarian Insufficiency/Early Menopause: a 23-Year Longitudinal Analysis

Source : https://academic.oup.com/humrep/advance-article/doi/10.1093/humrep/deae037/7613529?login=false

In this 23-year longitudinal study, by the age of 68 years, one-half of women with premature ovarian insufficiency/early menopause developed osteoporosis or a fracture.

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Menopause and the Role of Physical Activity - the Views and Knowledge of Women Aged 40-65

Menopause and the Role of Physical Activity - the Views and Knowledge of Women Aged 40-65

Source : https://pubmed.ncbi.nlm.nih.gov/38393976/

Menopause marks the end of female reproductive capacity. It is defined as the point after cessation of the menstrual cycle for 12 months (Nursat et al., 2008). Awareness about menopause...

This study found that women’s knowledge was not in line with their perceptions, perhaps in part due to where they are obtaining information.

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Treating Hot Flashes With Hypnosis: Does Hypnotizability Modulate Reductions?

Treating Hot Flashes With Hypnosis: Does Hypnotizability Modulate Reductions?

Source : https://pubmed.ncbi.nlm.nih.gov/38265698

Hypnosis is an effective treatment option for a variety of concerns. Past research has suggested that those who score in the high range of hypnotizability initially show greater improvement than...

Participants who were rated as either moderately or highly hypnotizable achieved a 50% reduction by Week 3 while those of low hypnotizability did not cross the 50% reduction threshold until the 12-week follow-up.

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