The impact of 17β-Estradiol on the Estrogen-Deficient Female Brain: From Mechanisms to Therapy With Hot Flushes as Target Symptoms
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10800853/
Sex steroids are essential for whole body development and functions. Among these steroids, 17β-estradiol (E2) has been known as the principal "female" hormone. However, E2's actions are not restricted to...
A noninvasive DHED prodrug approach may offer a translational value in terms of defining a therapeutic landscape to remedy the E2-deficient brain safely and efficaciously, including the alleviation or prevention of VMS.
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Obesity and Menopause
Source : https://pubmed.ncbi.nlm.nih.gov/38343134/
Obesity is not a choice or a result of lack of willpower, but a multifactorial, chronic, progressive, and relapsing disease. During menopause, hormonal and body composition changes lead to greater...
The use of estrogen-only or combined transdermal MHT does not increase the risk of thrombotic events in women with obesity.
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Passive Exercise Is an Effective Alternative to HRT for Restoring OVX Induced Mitochondrial Dysfunction in Skeletal Muscle
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10864566/
Postmenopausal women are more prone to develop muscle weakness, which is strongly associated with impairment of mitochondrial function in skeletal muscle. This study aimed to examine the impact of a...
Whole-body vibration training exhibits the ability to not only restore muscle weakness and mitochondrial dysfunction resulting from reduced estrogen levels but also to augment mitochondrial biogenesis.
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Safety and Efficacy of a Class II Medical Device Based on Highly Purified and Standardized Plant Extracts in the Management of Post-Menopausal Patients With Vulvar and Vaginal Atrophy: a Single-Center Prospective Observational Study
Source : https://pubmed.ncbi.nlm.nih.gov/38358384/
In women with GSM, the intravaginal administration of a hyaluronate-based gel enriched with purified botanical actives endowed with anti-inflammatory and mucosal-protecting properties, reduced painful sensation during sexual acts and increased...
In women with genitourinary syndrome of menopause, the intravaginal administration of a hyaluronate-based gel enriched with purified botanical actives endowed with anti-inflammatory and mucosal-protecting properties, reduced painful sensation during sexual acts and increased regular sexual activity.
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A Systematic Review and Critical Appraisal of Menopause Guidelines
Source : https://srh.bmj.com/content/early/2024/02/09/bmjsrh-2023-202099.long
To identify and appraise current national and international clinical menopause guidance documents, and to extract and compare the recommendations of the most robust examples.
The highest quality clinical practice guidelines consistently recommended menopausal hormone therapy for vasomotor symptoms and menopause-associated mood disturbance.
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