Estimation of placebo effect in randomized placebo-controlled trials for moderate or severe vasomotor symptoms: a meta-analysis
This study aimed to estimate placebo effects in randomized controlled trials (RCTs) fulfilling this guidance. Methods PubMed was searched using the following terms: "vasomotor symptom or hot flash or hot...
Conclusion: Substantial and consistent placebo effects were observed in RCTs for VMS treatment. These data suggest a reduction of 5.44 times per day in frequency and 0.36 in severity might be observed as a placebo effect.
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Impact of Menopause and the Menstrual Cycle on Oxidative Stress in Japanese Women
Source : https://www.mdpi.com/2077-0383/12/3/829
Although estrogen possesses both pro- and anti-oxidant properties, its overall role in oxidative stress among women remains unclear, particularly since the influence of exogenously administered estrogen during previous studies differed...
Conclusion: We found that oxidative stress, as evaluated by d-ROMs, was significantly higher in postmenopausal women than in premenopausal counterparts. However, there were no significant shifts in oxidative stress markers during the menstrual cycle. Additional studies are needed to fully understand the mechanisms by which endogenous estrogen...
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Effects of nutritional interventions on the severity of depressive and anxiety symptoms of women in the menopausal transition and menopause: a systematic review, meta-analysis, and meta-regression
Objective This systematic review and meta-analysis aimed to evaluate the effect of nutritional interventions on the severity of depressive (DS) and anxiety (AS) symptoms in women during the menopausal transition...
Conclusion: Nutritional interventions are promising tools for the management of mood/anxiety symptoms in women during the menopausal transition and in postmenopausal years. Because of significant heterogeneity and risk of bias among studies, the actual effect of different approaches is still unclear.
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Effects of mixed heavy metals on kidney function in premenopausal and postmenopausal women
2017), multivariate linear regression models, marginal effects, and weighted quantile sum regression, we assessed the associations between single heavy metals and their mixtures and eGFR among 5,372 women. Results Risks...
Conclusion: Postmenopausal women were more influenced by mixed heavy metals' effects on kidney function than premenopausal women. Early interventions (eg, water filtering, heavy metal yearly screening) in women, especially postmenopausal women, are needed to reduce the incidence of chronic kidney disease.
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Menopausal Status Contributes to Overall Survival in Endometrial Cancer Patients
Source : https://www.mdpi.com/2072-6694/15/2/451
Endometrial cancer is the most common female genital tract malignancy in developed countries that occurs predominantly in postmenopausal women. The primary objective of our research was to investigate whether menopause...
Conclusion: We have demonstrated here that some of the basic clinical variables related to men- strual status, such as time from last menstruation or postoperative FSH concentration, may contribute to overall survival in endometrial cancer patients.
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