Economic Evaluation of Four Treatment Strategies for Postmenopausal Patientswith Osteoporosis and a Recent Fracture in Mainland China: A Cost-Effectiveness Analysis
Source : https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4343743
Preprints with The Lancet is part of SSRN´s First Look, a place where journals identify content of interest prior to publication. Authors have opted in at submission to The Lancet...
Discussion: Stratified treatment based on very high fracture risk is more cost-effective than conventional pills in mainland China. Among the stratified treatments, zoledronate is the optimal option. Would this be similar in the USA?
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Late age at menopause positively associated with obesity-mediated hypertension - Hypertension Research
Source : https://www.nature.com/articles/s41440-023-01237-7
Hypertension Research (2023) Cite this article Menopause is an important process in women's lives. It is characterized by the loss of ovarian activity and permanent cessation of menses and diagnosed...
Conclusion: This study reveals a significant finding that maintaining a healthy body weight may be beneficial in preventing BP elevation after menopause, especially in women experiencing menopause at a late age. Further studies focusing on the associations between age at menopause and metabolic factors such as obesity, glycolipid metabolism,...
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Non-invasive biomechanical assessment of the prolapsed vaginal wall: an explorative pilot study on cutometry and indentometry - Scientific Reports
Source : https://www.nature.com/articles/s41598-023-29403-4
The clinical assessment of pelvic organ prolapse (POP) and associated treatment strategies is currently limited to anatomical and subjective outcome measures, which have limited reproducibility and do not include functional...
Conclusion: Compared to the reported indentation numbers of the skin, our results demonstrate higher indentation numbers, indicating lower vaginal tissue firmness than the skin. This is in line with our observation that vaginal tissue firmness—obtained with the Cutometer—was lower (higher Uf) than dermal tissue firmness described in the...
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Endogenous dehydroepiandrosterone and depression in postmenopausal women: a systematic review of observational studies
od effects. Objective This systematic review aimed to investigate the association between endogenous DHEA/DHEAS blood concentrations and depression/depressive symptoms in community-dwelling postmenopausal women. Evidence Review: Searches were conducted in Ovid...
Conclusion: This systematic review does not support an association between endogenous DHEA/DHEAS and depression in postmenopausal women.
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Rilmenidine extends lifespan and healthspan in Caenorhabditis elegans via a nischarin I1-imidazoline receptor - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36670049/
Repurposing drugs capable of extending lifespan and health span has a huge untapped potential in translational geroscience. Here, we searched for known compounds that elicit a similar gene expression signature...
Conclusion: this research presents a novel case for rilmenidine to be considered a potential calorie restriction mimetic through its prolongevity and health preserving effects, increased stress resistance, and increased autophagy. Alongside being a clinically approved antihypertensive drug, rilmenidine improves plasma lipid and blood glucose in...
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