Limited evidence of a threshold effect for increasing adiposity on risk of symptoms at midlife - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36166728/
doi: 10.1097/GME.0000000000002074. Online ahead of print. 1 From the Department of Anthropology, University of Massachusetts Amherst, Amherst, MA. 2 Department of Biostatistics and Epidemiology, University of Massachusetts Amherst, Amherst, MA....
Conclusion: Even at very high levels of BMI, likelihood of urinary incontinence and shortness of breath increases with BMI. In contrast, likelihood of aches/stiffness has a nonlinear relationship with BMI, increasing to a threshold level.
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The Potential Role of Serum IGF-1 and Leptin as Biomarkers: Towards Screening for and Diagnosing Postmenopausal Osteoporosis
Postmenopausal osteoporosis (PMOP) is a common type of osteoporosis (OP), which is a condition affecting approximately 33% women over 60yr in China. Estrogen is an essential element in the bone...
Conclusion: IFG-1 and leptin seem to be key biomarker associated with PMOP in this study. The high prevalence of PMOP makes these cytokines with highly attractive in clinical practice. Although we did not perform longitudinal assessments, IGF-1 and leptin might bear the potential of becoming a very useful screening test also for clinical...
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Surgical Menopause and Bilateral Oophorectomy: Effect of Estrogen-Progesterone and Testosterone Replacement Therapy on Psychological Well-being and Sexual Functioning; A Systematic Literature Review
Source : https://www.jsm.jsexmed.org/article/S1743-6095(22)01769-6/fulltext
Menopause can cause a variety of vasomotor, psychological, and sexual symptoms., , After a bilateral salpingo-oophorectomy at premenopausal age, eg, for reducing ovarian cancer risk or for removing benign disease,...
Conclusion: Independent randomized controlled clinical trials investigating the effects of estrogen-progesterone and testosterone on psychological and sexual symptoms after surgical menopause are needed.
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Early menopause and epigenetic biomarkers of ageing
Source : https://www.rbmojournal.com/article/S1472-6483(22)00710-6/fulltext
We read with interest Professor Laven's recent Countercurrent contribution stating that early menopause is a result of premature general ageing (Laven, 2022). In our opinion, his position is anything but...
Discussion: Currently available epigenetic clocks express the epigenetic age of individuals in contrast to their chronological age. These epigenetic biomarkers of ageing have proven themselves as compelling predictors of age-related conditions such as the cardiovascular disease.
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Mildly elevated diastolic blood pressure increases subsequent risk of breast cancer in postmenopausal women in the Health Examinees-Gem study - Scientific Reports
Source : https://www.nature.com/articles/s41598-022-19705-4
Epidemiological evidence suggests that hypertension is associated with breast cancer risk. However, previous studies disregard blood pressure components in the healthy population. We aimed to examine the relationship between systolic...
Conclusion: In summary, this study suggests that normal-high DBP values are associated with increased BC risk in postmenopausal women. We propose that mildly elevated DBP values are associated with an increased probability of BC, but they are not necessarily causal factors. Still, DBP could be used for the risk calculation of BC occurrence. Our...
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