The association between testosterone and depression in postmenopausal women: A systematic review of observational studies
The contribution of testosterone to depression in older women is uncertain. This review was conducted to investigate the association between endogenous testosterone blood concentrations and depression in postmenopausal women. We...
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Conclusion: While an association between testosterone and depression in postmenopausal women is not supported by this systematic review, this remains an uncertain conclusion due to methodologic limitations of the available data. Large, studies of community-based samples employing validated instruments for depression, and precise measurement...
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Menopausal Vasomotor Symptoms and White Matter Hyperintensities in Midlife Women
Source : https://n.neurology.org/content/100/2/e133.abstract
Background and Objectives The menopause transition is increasingly recognized as a time of importance for women's brain health. A growing body of work indicates that the classic menopausal symptom, vasomotor...
Discussion: VMS, particularly VMS occurring during sleep, were associated with greater WMHV. Identification of female-specific midlife markers of poor brain health later in life is critical to identify women who warrant early intervention and prevention. VMS have the potential to serve as female-specific midlife markers of brain health in...
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BEING: Bone Health in Aging Women with HIV: Impact of Switching Antiretroviral Therapy on Bone Mineral Density During the Perimenopausal Period
Source : https://www.liebertpub.com/doi/full/10.1089/aid.2022.0106
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Conclusion: Our cohort had reasonably good bone health despite years of HIV and TDF therapy, but we did observe a trend toward increased BMD with a switch from TDF to TAF. The perimenopausal period is an important time to assess reversible parameters affecting bone health.
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Estimation of placebo effect in randomized placebo-controlled trials for moderate or severe vasomotor symptoms: a meta-analysis
This study aimed to estimate placebo effects in randomized controlled trials (RCTs) fulfilling this guidance. Methods PubMed was searched using the following terms: "vasomotor symptom or hot flash or hot...
Conclusion: Substantial and consistent placebo effects were observed in RCTs for VMS treatment. These data suggest a reduction of 5.44 times per day in frequency and 0.36 in severity might be observed as a placebo effect.
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Impact of Menopause and the Menstrual Cycle on Oxidative Stress in Japanese Women
Source : https://www.mdpi.com/2077-0383/12/3/829
Although estrogen possesses both pro- and anti-oxidant properties, its overall role in oxidative stress among women remains unclear, particularly since the influence of exogenously administered estrogen during previous studies differed...
Conclusion: We found that oxidative stress, as evaluated by d-ROMs, was significantly higher in postmenopausal women than in premenopausal counterparts. However, there were no significant shifts in oxidative stress markers during the menstrual cycle. Additional studies are needed to fully understand the mechanisms by which endogenous estrogen...
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