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Navigating Menopause at Work: a Preliminary Study About Challenges and Support Systems

Navigating Menopause at Work: a Preliminary Study About Challenges and Support Systems

Source : https://pubmed.ncbi.nlm.nih.gov/38442310/

This study reveals an exigent need for increased awareness and structural changes to support working women going through menopause. The findings have far-reaching implications for not just promoting gender equity...

The severity of menopausal symptoms was found to significantly predict more emotional exhaustion, less work engagement, and greater turnover intentions.

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A Prospective Study on the Relationship Between Polycystic Ovary Syndrome and Age at Natural Menopause

A Prospective Study on the Relationship Between Polycystic Ovary Syndrome and Age at Natural Menopause

Source : https://journals.lww.com/menopausejournal/abstract/2024/02000/a_prospective_study_on_the_relationship_between.8.aspx

Of these, 348 women with PCOS based on the Rotterdam criteria and 1,348 non-PCOS controls were followed to assess the age at which they reached menopause.

The unadjusted accelerated failure time survival model revealed a significant positive association between polycystic ovary syndrome (PCOS) and age at natural menopause; women with PCOS experienced time to menopause by a factor of 1.05 than non-PCOS controls.

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Psychometric Evaluation of the MENQOL Instrument in Women Experiencing Vasomotor Symptoms Associated With Menopause

Psychometric Evaluation of the MENQOL Instrument in Women Experiencing Vasomotor Symptoms Associated With Menopause

Source : https://pubmed.ncbi.nlm.nih.gov/38396203/

ClinicalTrials.gov identifiers NCT04003155 and NCT04003142.

Overall, the results provided evidence of acceptable psychometric properties of the Menopause-Specific Quality of Life overall and domain scores using 1-week recall.

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Novel MOA targets age-old condition

Hot flashes—experienced by 70%-80% of menopausal women—are physically distressing and worsen quality of life. Newer therapies, such as NK3R antagonists, leverage a non-hormonal approach to addressing these symptoms.

For example, fezolinetant is a selective NK3R antagonist that directly blocks NKB from binding to the KNDy neuron. NKB is a known trigger of vasomotor symptoms (VMS).

KNDy neurons located at the level of the hypothalamus are inhibited by estrogen and triggered by the neuropeptide NKB, thus resulting in the regulation of body temperature.

During menopause, estrogen decline interferes with this balance involving NKB. Left unopposed, NKB signaling increases KNDy neuronal activity. This process sets off heat-dissipation mechanisms, such as vasodilation and sweating (or VMS).

Thus, fezolinetant helps decrease the frequency and intensity of hot flashes and night sweats, honing in on NK3R with an affinity 450 times higher than that of NK1 or NK2 receptors.

What are your thoughts on this new mechanism of action for the treatment of VMS?

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Bone Health in Women With Premature Ovarian Insufficiency/Early Menopause: a 23-Year Longitudinal Analysis

Source : https://academic.oup.com/humrep/advance-article/doi/10.1093/humrep/deae037/7613529?login=false

In this 23-year longitudinal study, by the age of 68 years, one-half of women with premature ovarian insufficiency/early menopause developed osteoporosis or a fracture.

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