Prevalence and Impact of Vasomotor Symptoms due to Menopause Among Women in Brazil, Canada, Mexico, and Nordic Europe: a Cross-Sectional Survey
Researchers surveyed women aged 40 to 65 years in Brazil, Canada, Mexico, and 4 Nordic European countries (Denmark, Finland, Norway, and Sweden) using an online survey. Secondary objectives assessed impact...
A total of 37,206 women across Brazil, Canada, Mexico, and 4 Nordic European countries accessed the survey. Across regions, 44% never received any pharmacologic treatment, and 16.9% and 5.2% of respondents were taking prescription HT and non-HT medications, respectively, at the time of the survey.
Share
Fezolinetant blocks NKB binding on the kisspeptin/neurokinin B/dynorphin neuron, which modulates neuronal activity in the thermoregulatory center and decreases the number and intensity of hot flashes and night sweats.
Share
Relationships Between the Vaginal Microbiota and Genitourinary Syndrome of Menopause Symptoms in Postmenopausal Women: the Study of Women's Health Across the Nation
Source : https://pubmed.ncbi.nlm.nih.gov/37788422/
Although close relationships exist among estrogen, CSTs, VMI, and pH, sexual pain was the only GSM symptom associated with the structure of vaginal microbiota and atrophy biomarkers.
Although close relationships exist among estrogen, community state types, vaginal maturation index, and pH, sexual pain was the only symptom of the genitourinary syndrome of menopause associated with the structure of vaginal microbiota and atrophy biomarkers.
Share
This article describes the use of fezolinetant and neurokinin B antagonists as nonhormonal therapies for menopausal vasomotor symptoms.
Share
Insights Into the Genetics of Menopausal Vasomotor Symptoms: Genome-Wide Analyses of Routinely-Collected Primary Care Health Records
Source : https://bmcmedgenomics.biomedcentral.com/articles/10.1186/s12920-023-01658-w
Vasomotor symptoms (VMS) can often significantly impact women's quality of life at menopause. In vivo studies have shown that increased neurokinin B (NKB) / neurokinin 3 receptor (NK3R) signalling contributes...
In this large study of menopausal VMS derived from primary care health records, researchers demonstrated the potential of routine health care data for deriving phenotypes not available in self-reported study data.
Share