Non-invasive biomechanical assessment of the prolapsed vaginal wall: an explorative pilot study on cutometry and indentometry - Scientific Reports
Source : https://www.nature.com/articles/s41598-023-29403-4
The clinical assessment of pelvic organ prolapse (POP) and associated treatment strategies is currently limited to anatomical and subjective outcome measures, which have limited reproducibility and do not include functional...
Conclusion: Compared to the reported indentation numbers of the skin, our results demonstrate higher indentation numbers, indicating lower vaginal tissue firmness than the skin. This is in line with our observation that vaginal tissue firmness—obtained with the Cutometer—was lower (higher Uf) than dermal tissue firmness described in the...
Endogenous dehydroepiandrosterone and depression in postmenopausal women: a systematic review of observational studies
od effects. Objective This systematic review aimed to investigate the association between endogenous DHEA/DHEAS blood concentrations and depression/depressive symptoms in community-dwelling postmenopausal women. Evidence Review: Searches were conducted in Ovid...
Conclusion: This systematic review does not support an association between endogenous DHEA/DHEAS and depression in postmenopausal women.
Rilmenidine extends lifespan and healthspan in Caenorhabditis elegans via a nischarin I1-imidazoline receptor - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36670049/
Repurposing drugs capable of extending lifespan and health span has a huge untapped potential in translational geroscience. Here, we searched for known compounds that elicit a similar gene expression signature...
Conclusion: this research presents a novel case for rilmenidine to be considered a potential calorie restriction mimetic through its prolongevity and health preserving effects, increased stress resistance, and increased autophagy. Alongside being a clinically approved antihypertensive drug, rilmenidine improves plasma lipid and blood glucose in...
Is HRT overprescribed? - The Pharmaceutical Journal
Source : https://pharmaceutical-journal.com/article/feature/is-hrt-overprescribed
As general awareness of menopausal symptoms has increased, there has been a rapid rise in prescriptions for hormone replacement therapy (HRT), which is - of course - a good thing,...
Discussion: It is evident that there are cases where HRT is being overprescribed; specifically, private providers being prescribed doses above the licence recommendations. This has been recognised as an issue by the BMS and is in the process of being addressed.
Network analysis of eating disorder symptoms in women in perimenopause and early postmenopause
ggest that EDs and related symptoms may be more prevalent in midlife aged women during perimenopause compared with midlife aged women at pre-menopause. To date few studies have examined the...
Conclusion: Results corroborate previous studies and indicate that, similar to young adult samples, dissatisfaction with body image is a core feature of ED pathology across the lifespan.