Late age at menopause positively associated with obesity-mediated hypertension - Hypertension Research
Source : https://www.nature.com/articles/s41440-023-01237-7
Hypertension Research (2023) Cite this article Menopause is an important process in women's lives. It is characterized by the loss of ovarian activity and permanent cessation of menses and diagnosed...
Conclusion: This study reveals a significant finding that maintaining a healthy body weight may be beneficial in preventing BP elevation after menopause, especially in women experiencing menopause at a late age. Further studies focusing on the associations between age at menopause and metabolic factors such as obesity, glycolipid metabolism,...
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Non-invasive biomechanical assessment of the prolapsed vaginal wall: an explorative pilot study on cutometry and indentometry - Scientific Reports
Source : https://www.nature.com/articles/s41598-023-29403-4
The clinical assessment of pelvic organ prolapse (POP) and associated treatment strategies is currently limited to anatomical and subjective outcome measures, which have limited reproducibility and do not include functional...
Conclusion: Compared to the reported indentation numbers of the skin, our results demonstrate higher indentation numbers, indicating lower vaginal tissue firmness than the skin. This is in line with our observation that vaginal tissue firmness—obtained with the Cutometer—was lower (higher Uf) than dermal tissue firmness described in the...
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Endogenous dehydroepiandrosterone and depression in postmenopausal women: a systematic review of observational studies
od effects. Objective This systematic review aimed to investigate the association between endogenous DHEA/DHEAS blood concentrations and depression/depressive symptoms in community-dwelling postmenopausal women. Evidence Review: Searches were conducted in Ovid...
Conclusion: This systematic review does not support an association between endogenous DHEA/DHEAS and depression in postmenopausal women.
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Rilmenidine extends lifespan and healthspan in Caenorhabditis elegans via a nischarin I1-imidazoline receptor - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36670049/
Repurposing drugs capable of extending lifespan and health span has a huge untapped potential in translational geroscience. Here, we searched for known compounds that elicit a similar gene expression signature...
Conclusion: this research presents a novel case for rilmenidine to be considered a potential calorie restriction mimetic through its prolongevity and health preserving effects, increased stress resistance, and increased autophagy. Alongside being a clinically approved antihypertensive drug, rilmenidine improves plasma lipid and blood glucose in...
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Is HRT overprescribed? - The Pharmaceutical Journal
Source : https://pharmaceutical-journal.com/article/feature/is-hrt-overprescribed
As general awareness of menopausal symptoms has increased, there has been a rapid rise in prescriptions for hormone replacement therapy (HRT), which is - of course - a good thing,...
Discussion: It is evident that there are cases where HRT is being overprescribed; specifically, private providers being prescribed doses above the licence recommendations. This has been recognised as an issue by the BMS and is in the process of being addressed.
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