Factors associated with weight gain in pre- and post-menopausal women receiving adjuvant endocrine therapy for breast cancer - Journal of Cancer Survivorship
Source : https://link.springer.com/article/10.1007/s11764-023-01408-y
Purpose Weight gain after breast cancer poses health risks. We aimed to identify factors associated with weight gain during adjuvant endocrine therapy (AET). Methods Women initiating AET enrolled in a...
Conclusion: Weight gain during AET is common, especially for pre-menopausal women. Clinicodemographic features and early treatment-emergent symptoms may identify at risk individuals.
Sex and gender influence on immunity and autoimmunity
Source : https://www.frontiersin.org/articles/10.3389/fimmu.2023.1142723/full
Autoimmune diseases are skewed toward one biological sex or another. This is the obvious observation of many decades, and it remains unexplained. Females predominate with most autoimmune diseases. The reasons...
Conclusion: The interplay between genetics and sex steroid metabolism within the body is how the immune response handles infections and regulates immune function. The reasons for the female predilection for autoimmune disease remains unknown but is likely due to the genetics of the X chromosome, hormonal regulation of immune cells (CD4 T...
Investigating the efficacy and feasibility of using a whole-of-diet approach to lower circulating levels of C-reactive protein in postmenopausal women: a mixed methods pilot study
protein in weight stable postmenopausal women with abdominal obesity. Methods This mixed-methods pilot study used a single arm pre-post design. Thirteen women followed a 4-week anti-inflammatory, dietary intervention, optimizing consumption...
Conclusion: Weight-neutral dietary interventions targeting inflammation can improve metabolic markers and may be a viable strategy for CVD risk reduction in postmenopausal women. To determine effects on inflammatory status, a fully powered and longer-term randomized controlled trial is required.
Prevalence of Metabolic Syndrome and Its Association With Menopausal Symptoms in Post-Menopausal Women: A Scoping Review
Complex metabolic dysregulation leads to metabolic syndrome (MetS) causing various symptoms such as type II diabetes, central obesity, cardiovascular diseases (CVD), altered glucose metabolism, hypertension, and dyslipidemia, and is thought...
Conclusion: This review concludes that MetS is more common in post-menopausal women and are more likely to experience somatic complaints and a positive correlation of vasomotor symptoms with MetS, in comparison to pre-menopausal women which is due to estrogen shortage and fat redistribution. Additionally, in older and obese women, the...
The association of hysterectomy with or without ovarian conservation with subclinical atherosclerosis progression in healthy postmenopausal women
to hormone therapy or placebo in the Early versus Late Intervention Trial with Estradiol (ELITE), which was conducted from July 2005 to February 2013. Subclinical atherosclerosis progression was measured as...
Conclusion: Hysterectomy with bilateral oophorectomy and ovarian conservation were associated with greater subclinical atherosclerosis progression relative to natural menopause. The associations were stronger for later age and longer time since oophorectomy/hysterectomy. Further research should continue to examine long-term atherosclerosis...