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Antidepressant Use to Treat Menopausal Vasomotor Symptoms

It is estimated that close to 40% of the world's 1.2 billion women will be post-menopausal or menopausal by 2030. That's nearly 50 million women and, among those, ~60-70% are likely to suffer from menopausal symptoms. Although hormone therapy (HT) is suggested for curtailing both vasomotor symptoms and mood disturbances, HT treatment continues to be controversial. Aside from breast cancer and cardiovascular concerns, research shows that HT itself might also increase the risk of depression.

In a recent discussion among OB-GYNs and primary care clinicians, about half stated they treat menopausal vasomotor symptoms with antidepressants such as SSRIs, SNRIs, and bupropion. While there was agreement that the treatment may not address all of the symptoms, research has confirmed that antidepressants are effective in treating both depression and vasomotor symptoms shortly before, during, and after menopause.

Which antidepressant(s) do you find most effective for the treatment of menopause? Have you observed whether these are the same antidepressants that work in younger women for premenstrual dysphoric disorder?

  • 3yr
    Brisdelle not only helps my patients with their VMS, but I have found it also helps mood improvement as menopause can be difficult emotionally for many. I have patients take Show More
  • 3yr
    Effexor and Prozac are useful too. Many of the SSRIs and SNRIs are effective by helping to reduce hot flashes, night sweats and mood swings.

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Monoclonal anti-CGRP antibodies in post-menopausal women: a real-life study - Acta Neurologica Belgica

Monoclonal anti-CGRP antibodies in post-menopausal women: a real-life study - Acta Neurologica Belgica

Source : https://link.springer.com/article/10.1007/s13760-023-02190-5

Introduction Migraine usually ameliorates after menopause. However, 10-29% of women still experience migraine attacks after menopause, especially if menopause is surgical. The use of monoclonal antibodies against the calcitonin gene-related...



Discussion: The effectiveness of anti-CGRP monoclonal antibodies is almost the same between women in menopause and women of childbearing age, without appreciable differences between the different antibodies.

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Factors underpinning an improved menopausal experience in the workplace for doctors: a UK-based qualitative study

Factors underpinning an improved menopausal experience in the workplace for doctors: a UK-based qualitative study

Source : https://bmjopen.bmj.com/content/13/3/e060265?rss=1

Objectives A recent British Medical Association survey revealed that very few National Health Service (NHS) doctors felt comfortable discussing symptoms with their managers, and many feel unable to make changes...



Conclusion: This study highlights that doctors’ factors underpinning an IME in the workplace are comparable to other sectors. The potential benefits of an IME for doctors in the NHS are considerable. NHS leaders can address these challenges by using pre-existing training materials and resources for their employees if menopausal doctors are...

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Menopause Is Associated with Obstructive Sleep Apnea in a Population-Based Sample from Mecklenburg-Western Pomerania, Germany

Menopause Is Associated with Obstructive Sleep Apnea in a Population-Based Sample from Mecklenburg-Western Pomerania, Germany

Source : https://www.mdpi.com/2077-0383/12/6/2101/htm

Objective: Menopause is associated with multiple health risks. In several studies, a higher incidence or a higher risk for obstructive sleep apnea (OSA) in post-menopausal than pre-menopausal women is reported....



Conclusion: In our current study, we were able to replicate the findings of two other population-based studies confirming a higher OSA risk in post-menopausal women. We expanded these findings by visualizing this effect using splines. While our study cannot contribute to disentangling the (most likely) hormonal mechanism causing this effect, it...

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Anti-Müllerian Hormone Level Decline in Patients Undergoing Hysterectomy With and Without Oophorectomy Compared With Natural Menopause

Anti-Müllerian Hormone Level Decline in Patients Undergoing Hysterectomy With and Without Oophorectomy Compared With Natural Menopause

Source : https://journals.lww.com/greenjournal/Abstract/2023/02000/Anti_M_llerian_Hormone_Level_Decline_in_Patients.11.aspx

derwent hysterectomy (159 with bilateral salpingo-oophorectomy [BSO], 13 with one ovary conserved, and 60 with both ovaries conserved) and who had serial AMH measurements were included from SWAN (The Study...



Hysterectomy does not lead to a more rapid decline in AMH levels postoperatively compared with natural menopause. Patients undergoing BSO have a rapid loss of AMH, consistent with complete removal of the ovaries. These data suggest that hysterectomy as currently performed does not compromise ovarian reserve.