Cognitive decline and dementia in women after menopause: Prevention strategies
Source : https://www.maturitas.org/article/S0378-5122(22)00235-3/fulltext
Cognitive decline (CD) and dementia constitute a public health problem worldwide. The associations between the length of the reproductive period, the onset of menopause, and neurogenerative disorders have been well...
Discussion: There is currently no biomarker of cognitive decline and no prophylactic treatment. Even though a growing amount of data is supporting lifestyle and nutritional modification to control the possible onset of cognitive decline, primary prevention strategies dedicated to the postmenopausal group of the population are still lacking....
Conclusion: In this secondary analysis of a randomized clinical trial, a significant, although small, increase in serum estradiol levels was noted after 12 weeks of vaginal estrogen administration. The clinical relevance of this small increase is uncertain.
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Menopause Connect3yrKey Points • Source: JAMA Network Open • Meaning: “Low-dose vaginal estradiol use was associated with a small increase in serum estradiol concentrations of uncertain clinical significance.” • In the current secondary analysis of randomized clinical Show More
Conclusion: These findings suggest that systemically administered HT before and during menopause is associated with higher risk of depression, especially in the years immediately after initiation, whereas locally administered HT is associated with lower risk of depression for women 54 years or older.
Conclusion: In this randomized clinical trial, 8-wk combined treatment with PFMT EA led to a greater improvement in SUI symptoms and better outcomes than with PFMT sham EA.
Can precision medicine get us through menopause?
Source : https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(22)00544-8/fulltext
Women spend up to three decades in the post-menopausal phase of life, which is often accompanied by a wide variety of life-disrupting symptoms, including vasomotor symptoms, sleep disturbances, cognitive decline,...
Discussion: Using the comprehensive broad database generated, statistical mediation analyses were performed to lend insight into mechanisms driving the observed changes. These analyses revealed some novel and potentially important associations between diet, gut microbial changes, and health indicators.