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Treating Vasomotor Menopause Symptoms

Eighty percent (80%) of women aged 40-65 years reported having vasomotor menopausal symptoms (VMS) according to a survey of 4,754 women published in Menopause, The Journal of The North American Menopause Society. Vasomotor menopausal symptoms include hot flashes and night sweats or cold sweats. Insomnia, irritability, and trouble concentrating are additional symptoms often cited by patients.

Fifty-five percent (55%) of the surveyed women reported their vasomotor symptoms as moderate to severe, and more than half of these women were untreated. VMS has a substantial negative impact on women’s personal and professional lives, which increases with the severity of symptoms.

While hormone therapy is still widely used to treat VMS, there continue to be concerns about risks of venous thromboembolism, stroke, and breast cancer. According to the women surveyed, ~35% were hormone therapy-contraindicated and ~50% were hormone-therapy cautious or averse.

Have you seen similar statistics in your practice? What have you found to be successful in treating VMS with patients who are HRT-contraindicated or averse?

  • 3yr
    Since I am a Psych NP, I mainly use SSRI's and SNRI's which are somewhat effective for some. The numbers do seem similar to what I see.
  • 3yr
    Numerous studies have shown the strong correlation between VMS and endothelial dysfunction and increase rate of heart disease. I strongly disagree with treating symptoms.

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Women with Schizophrenia-Spectrum Disorders After Menopause: A Vulnerable Group for Relapse - PubMed

Women with Schizophrenia-Spectrum Disorders After Menopause: A Vulnerable Group for Relapse - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/36198044/

While younger women have a lower risk of relapse and generally need a lower antipsychotic dose to prevent rehospitalization than men, antipsychotic effectiveness declines in women after the age of...


Conclusion: While younger women have a lower risk of relapse and generally need a lower antipsychotic dose to prevent rehospitalization than men, antipsychotic effectiveness declines in women after the age of 45. Starting in mid-forties, older women with SSD should be regarded as a vulnerable group that deserve special attention.

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The clinical management of testosterone replacement therapy in postmenopausal women with hypoactive sexual desire disorder: a review - International Journal of Impotence Research

The clinical management of testosterone replacement therapy in postmenopausal women with hypoactive sexual desire disorder: a review - International Journal of Impotence Research

Source : https://www.nature.com/articles/s41443-022-00613-0

As women age, there is an overall decrease in androgen production due to decline of ovarian and adrenal function during menopause. Androgens have been demonstrated to play an important role...


Conclusion: TRT is an effective treatment option for postmenopausal people with HSDD as testosterone is vital to sexual function and health. There is still limited data on the effectiveness in premenopausal people with HSDD.

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Evaluation of atherosclerosis-related biomarkers during perimenopause: A prospective cohort study in women with endometriosis - PubMed

Evaluation of atherosclerosis-related biomarkers during perimenopause: A prospective cohort study in women with endometriosis - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/36168257/

doi: 10.1111/jog.15447. Online ahead of print. 1 Department of Obstetrics and Gynecology, The University of Tokyo, Tokyo, Japan. 2 Department of Preventive Medicine for Locomotive Organ Disorders, 22nd Century Medical...


Conclusion: The association between CAVI and serum markers related to lipid metabolism and ovarian function was mild. Longitudinal analysis of CAVI showed an association with pentosidine, which may be helpful in assessing atherosclerosis risk in women with endometriosis during perimenopause.

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Cardiovascular Disease in Women: Does Menopause Matter?

Cardiovascular Disease in Women: Does Menopause Matter?

Source : https://www.sciencedirect.com/science/article/abs/pii/S2451965022001041

Available online 6 October 2022, 100419 It is known that the menopause transition (MT) is a complex period during a woman's life, but there has been ongoing debate on whether...


Discussion: The accumulated data support incorporating menopause-related factors as important components of CVD risk assessment in clinical practice of midlife women.